Detailed information of TA system TA168370

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1600862..1601441
• Replicon: chromosome
• Accession: NZ_CP059155
• Organism: Staphylococcus aureus strain WKZ-2

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: HTZ91_RS07610
• Protein ID: WP_001025401.1
• Coordinates: 1601196..1601441 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1600862..1601227 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HTZ91_RS07570	1597605..1598162	-	558	WP_000645048.1	DUF2815 family protein	-
HTZ91_RS07575	1598188..1599354	-	1167	WP_180821674.1	DUF2800 domain-containing protein	-
HTZ91_RS07580	1599351..1599713	-	363	WP_000985972.1	hypothetical protein	-
HTZ91_RS07585	1599728..1600051	-	324	WP_000174998.1	hypothetical protein	-
HTZ91_RS07590	1600130..1600291	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
HTZ91_RS07595	1600304..1600567	-	264	WP_001124157.1	helix-turn-helix domain-containing protein	-
HTZ91_RS07600	1600592..1600807	-	216	WP_001097552.1	hypothetical protein	-
HTZ91_RS07605	1600862..1601227	+	366	WP_001128433.1	hypothetical protein	Antitoxin
HTZ91_RS07610	1601196..1601441	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
HTZ91_RS07615	1601491..1601709	-	219	WP_001001383.1	hypothetical protein	-
HTZ91_RS07620	1601725..1602280	-	556	Protein_1498	phage antirepressor KilAC domain-containing protein	-
HTZ91_RS07625	1602306..1602533	-	228	WP_001030311.1	hypothetical protein	-
HTZ91_RS07630	1602705..1603319	+	615	WP_000801423.1	XRE family transcriptional regulator	-
HTZ91_RS07635	1603335..1604255	+	921	WP_000348133.1	3'-5' exoribonuclease	-
HTZ91_RS07640	1604351..1604533	+	183	WP_000705240.1	hypothetical protein	-
HTZ91_RS07645	1604570..1604716	+	147	WP_180821745.1	hypothetical protein	-
HTZ91_RS07650	1604716..1605327	-	612	Protein_1504	ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	gnd	1562306..1631966	69660

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T168370 WP_001025401.1 NZ_CP059155:c1601441-1601196 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T168370 NZ_CP075737:c1947200-1946865 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTATTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT168370 NZ_CP059155:1600862-1601227 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin