Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1593831..1594254 Replicon chromosome
Accession NZ_CP059155
Organism Staphylococcus aureus strain WKZ-2

Toxin (Protein)


Gene name higB Uniprot ID A0A6B5KJM6
Locus tag HTZ91_RS07535 Protein ID WP_001065110.1
Coordinates 1594003..1594254 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E1X568
Locus tag HTZ91_RS07530 Protein ID WP_000028425.1
Coordinates 1593831..1594013 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HTZ91_RS07490 1589224..1589514 - 291 WP_000665205.1 VRR-NUC domain-containing protein -
HTZ91_RS07495 1589648..1589752 + 105 WP_180821673.1 hypothetical protein -
HTZ91_RS07500 1589855..1592302 - 2448 WP_000884879.1 virulence-associated E family protein -
HTZ91_RS07505 1592355..1592555 - 201 WP_000265258.1 DUF1514 family protein -
HTZ91_RS07510 1592623..1592775 - 153 WP_000595237.1 transcriptional activator RinB -
HTZ91_RS07515 1592768..1593004 - 237 WP_000483477.1 hypothetical protein -
HTZ91_RS07520 1593029..1593265 - 237 WP_000195806.1 DUF1381 domain-containing protein -
HTZ91_RS07525 1593302..1593838 - 537 WP_000185703.1 dUTPase -
HTZ91_RS07530 1593831..1594013 - 183 WP_000028425.1 hypothetical protein Antitoxin
HTZ91_RS07535 1594003..1594254 - 252 WP_001065110.1 DUF1024 family protein Toxin
HTZ91_RS07540 1594269..1594511 - 243 WP_000132193.1 hypothetical protein -
HTZ91_RS07545 1594526..1594726 - 201 WP_000235324.1 hypothetical protein -
HTZ91_RS07550 1594729..1594986 - 258 WP_000022730.1 DUF3310 domain-containing protein -
HTZ91_RS07555 1594986..1595387 - 402 WP_000113974.1 PVL family protein -
HTZ91_RS07560 1595387..1595572 - 186 WP_001164629.1 DUF3113 family protein -
HTZ91_RS07565 1595585..1597537 - 1953 WP_001802096.1 DNA polymerase -
HTZ91_RS07570 1597605..1598162 - 558 WP_000645048.1 DUF2815 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - gnd 1562306..1631966 69660


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9405.32 Da        Isoelectric Point: 3.8051

>T168369 WP_001065110.1 NZ_CP059155:c1594254-1594003 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T168369 NZ_CP075737:c1161625-1161374 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6781.65 Da        Isoelectric Point: 4.4421

>AT168369 WP_000028425.1 NZ_CP059155:c1594013-1593831 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDGSIISLIDFVIKPIHLIKEAQEND

Download         Length: 183 bp

>AT168369 NZ_CP075737:c1161377-1161123 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATTTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B5KJM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1X568

References