Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3923884..3924577 Replicon chromosome
Accession NZ_CP059125
Organism Escherichia coli strain EC45

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag H0X93_RS18925 Protein ID WP_000415585.1
Coordinates 3924281..3924577 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag H0X93_RS18920 Protein ID WP_000650107.1
Coordinates 3923884..3924279 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0X93_RS18910 (3919748) 3919748..3922006 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
H0X93_RS18915 (3922144) 3922144..3923751 - 1608 WP_001375094.1 ABC transporter substrate-binding protein -
H0X93_RS18920 (3923884) 3923884..3924279 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
H0X93_RS18925 (3924281) 3924281..3924577 - 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
H0X93_RS18930 (3924782) 3924782..3925264 - 483 WP_000183505.1 GyrI-like domain-containing protein -
H0X93_RS18935 (3925317) 3925317..3925709 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
H0X93_RS18940 (3925861) 3925861..3926520 + 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
H0X93_RS18945 (3926517) 3926517..3927866 + 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
H0X93_RS18950 (3927912) 3927912..3928244 - 333 WP_000914690.1 DUF2645 family protein -
H0X93_RS25165 (3928251) 3928251..3928961 - 711 WP_000834030.1 hypothetical protein -
H0X93_RS25170 (3928964) 3928964..3929443 - 480 WP_000065332.1 Hcp family type VI secretion system effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T168315 WP_000415585.1 NZ_CP059125:c3924577-3924281 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T168315 NZ_CP075719:c54667-54386 [Escherichia coli]
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT168315 WP_000650107.1 NZ_CP059125:c3924279-3923884 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT168315 NZ_CP075719:c54908-54657 [Escherichia coli]
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References