Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 711411..712104 Replicon chromosome
Accession NZ_CP059119
Organism Escherichia coli strain Ec42

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag H0X94_RS03450 Protein ID WP_000415584.1
Coordinates 711411..711707 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag H0X94_RS03455 Protein ID WP_000650107.1
Coordinates 711709..712104 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0X94_RS03415 (706499) 706499..706813 - 315 WP_000958598.1 putative quinol monooxygenase -
H0X94_RS03420 (706844) 706844..707425 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
H0X94_RS03425 (707744) 707744..708076 + 333 WP_023149630.1 DUF2645 family protein -
H0X94_RS03430 (708122) 708122..709471 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
H0X94_RS03435 (709468) 709468..710127 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
H0X94_RS03440 (710279) 710279..710671 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
H0X94_RS03445 (710724) 710724..711206 + 483 WP_000183505.1 GyrI-like domain-containing protein -
H0X94_RS03450 (711411) 711411..711707 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
H0X94_RS03455 (711709) 711709..712104 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
H0X94_RS03460 (712237) 712237..713844 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
H0X94_RS03465 (713982) 713982..716240 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T168262 WP_000415584.1 NZ_CP059119:711411-711707 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T168262 NZ_CP075689:11361-11711 [Pseudomonas amygdali pv. lachrymans]
ATGACTACATTTGCACTGCGCTTTACCGAGGTTGCGCAGCAAAGCCTTGAAGATCAGGTTGAACACTTGGCTGTCACTCA
GGGGTTTTCATCAGCTGCTCGACGTATAGATTCCCTGATCGATGCCATTCAGGACAAGCTCCTGTCCACTCCGTTGGGCT
ACCCGGTCAGTCCTCAATTGAGTGAGCTGGGCGTATTGCACTATCGTGAGTTGAACACTGACGGATACCGAATCTTTTAC
GAGGTGATGGATTCAGGTGGTATTACCGGCATCGTCGTATTGCTCGTATTAGGTGGTAAACAAAGTGTTGAACAGGCATT
GATCCGCTATTGCCTGCTTCAACTTATTTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT168262 WP_000650107.1 NZ_CP059119:711709-712104 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT168262 NZ_CP075689:11100-11348 [Pseudomonas amygdali pv. lachrymans]
ATGCGAGTTGAAACAATAAGTTATCTGAAACGTAACGCAGCCGACCTGCCTCTCGATGAGCCACTGGTTGTCACGCAAAA
CGGTGTGCCGGCCTACGTGGTGGAGTCTTACGCAGATCGTAAGCGCCGCGATGAGTCCATCGCCTTAGTGAAGCTCCTGG
CAATCAGCTCTCGCGAATACTCCCAAGGCAAGCACTGTTCCACTGACGAACTCAAAGCCCGATTGAGCAGGAGGTTTGAT
CACAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References