Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 189896..190617 Replicon plasmid pAR1aA
Accession NZ_CP059091
Organism Pantoea agglomerans strain AR1a

Toxin (Protein)


Gene name higB Uniprot ID A0A8X8J2A8
Locus tag H0Z11_RS21885 Protein ID WP_010247063.1
Coordinates 189896..190207 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H0Z11_RS21890 Protein ID WP_208003524.1
Coordinates 190204..190617 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0Z11_RS21875 (H0Z11_21870) 186599..187891 - 1293 WP_208003523.1 lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family protein -
H0Z11_RS21880 (H0Z11_21875) 187902..189455 - 1554 WP_109651585.1 aspartate aminotransferase family protein -
H0Z11_RS21885 (H0Z11_21880) 189896..190207 + 312 WP_010247063.1 type II toxin-antitoxin system HigB family toxin Toxin
H0Z11_RS21890 (H0Z11_21885) 190204..190617 + 414 WP_208003524.1 helix-turn-helix domain-containing protein Antitoxin
H0Z11_RS21895 (H0Z11_21890) 190732..192105 - 1374 WP_208003525.1 PTS ascorbate transporter subunit IIC -
H0Z11_RS21900 (H0Z11_21895) 192145..192417 - 273 WP_208003526.1 PTS sugar transporter subunit IIB -
H0Z11_RS21905 (H0Z11_21900) 192466..192915 - 450 WP_208003527.1 PTS sugar transporter subunit IIA -
H0Z11_RS21910 (H0Z11_21905) 193360..194094 + 735 WP_010247068.1 GntR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..557771 557771


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12207.12 Da        Isoelectric Point: 9.8340

>T168258 WP_010247063.1 NZ_CP059091:189896-190207 [Pantoea agglomerans]
MHIISRGPFREAAIIYPNHASALDAAYLVLRDENFATPDALKIRFQSLDRMKYREKWWVIDVGGNSLRIMFYADFDRGKI
FIKHIVTHAEYDKLVKKYRESKE

Download         Length: 312 bp

>T168258 NZ_CP075686:5289328-5289618 [Pseudomonas amygdali pv. lachrymans]
ATGAACAACGAGACGACACCGTTCGATACCGTCGACTATTTGAAGACACCTGAAGATATGGCCAATTATCTGGATGCGTG
TCTTGAAGAGGATTCAGGAGACGGGCTGCTCGTAAGGGCCGCGCTGAACGACATAGCAAGGGCTTATGGCATGACACAAA
TCGCACGTGATACAGGTCTTGGTCGTGAGAGCCTCTACAAAGCGCTGGGTGCAAACGGTAATCCAGAGTTCACGACCATC
ATGAAAGTCGTGAGGGCGATGGGGATCAAACTACACGCAAGTACGCGCTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15432.50 Da        Isoelectric Point: 4.9795

>AT168258 WP_208003524.1 NZ_CP059091:190204-190617 [Pantoea agglomerans]
MITEAIQATNDLVRIVPFLGGSTDKRDYEQALELVEYLVEHQPDSPLVEILSDKVARYENSAPEFAAFNARIDAMPRGVA
LLRVIMDQHGLTQSSFADEIGQRSYVSRILRGDRPLTDKHKARLAARFNLPFEAFAE

Download         Length: 414 bp

>AT168258 NZ_CP075686:5289023-5289325 [Pseudomonas amygdali pv. lachrymans]
ATGAATCGCTTTGAACAGACGCCCGCTTTTGCGGAGTGGTTAAGGTCGTTGAAGGACTCCATTGGCAGAGCTCGAATTCT
GGCTCGAATAAGAGCAGCAGAGCTCGGTAACTTCGGGGACTGCGATGCTTTAGGTCAAGGCGTCAGAGAGCTACGAATAC
ACCATGGACCAGGTTATCGGGTGTATTTTGCCCGACGCACGGGTGTGGTTTACCTGCTCTTGATCGCTGGTGACAAATCG
TCTCAAAAGCGCGACATAAAATTTGCCAGACAGCTGGCGAGAGAGCTCTGTGAGAGGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References