Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 69534..70185 Replicon plasmid pAR1aA
Accession NZ_CP059091
Organism Pantoea agglomerans strain AR1a

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H0Z11_RS21330 Protein ID WP_069026837.1
Coordinates 69534..69878 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H0Z11_RS21335 Protein ID WP_115764773.1
Coordinates 69871..70185 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0Z11_RS21310 (H0Z11_21305) 65865..66335 + 471 WP_031594134.1 GNAT family N-acetyltransferase -
H0Z11_RS21315 (H0Z11_21310) 66439..67317 + 879 WP_033768811.1 23S rRNA pseudouridine(2604) synthase RluF -
H0Z11_RS21320 (H0Z11_21315) 67376..68434 - 1059 WP_208003438.1 SDR family oxidoreductase -
H0Z11_RS21325 (H0Z11_21320) 68532..69452 + 921 WP_208003440.1 LysR family transcriptional regulator -
H0Z11_RS21330 (H0Z11_21325) 69534..69878 + 345 WP_069026837.1 toxin Toxin
H0Z11_RS21335 (H0Z11_21330) 69871..70185 + 315 WP_115764773.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
H0Z11_RS21340 (H0Z11_21335) 70394..71065 + 672 WP_115388259.1 hypothetical protein -
H0Z11_RS21345 (H0Z11_21340) 71156..72007 - 852 WP_208003442.1 Vmh family MBL fold metallo-hydrolase -
H0Z11_RS21350 (H0Z11_21345) 72154..73035 + 882 WP_143789341.1 LysR family transcriptional regulator -
H0Z11_RS21355 (H0Z11_21350) 73074..73493 + 420 WP_208003444.1 VOC family protein -
H0Z11_RS21360 (H0Z11_21355) 73980..74282 + 303 WP_115764777.1 type 1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..557771 557771


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin MqsA/HigA-2

(18-100)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13486.26 Da        Isoelectric Point: 9.6381

>T168257 WP_069026837.1 NZ_CP059091:69534-69878 [Pantoea agglomerans]
MDALFIELSSFQKYRADYLNDDQYRLFQNMLLADPEKGDVIPDTGGLRKVRFRDERRHKGARGGIRVIYYWTNTQGQFIL
FTIYDKDQRDDLTRQQRDALATALNVIKKGLRHD

Download         Length: 345 bp

>T168257 NZ_CP075686:5289023-5289325 [Pseudomonas amygdali pv. lachrymans]
ATGAATCGCTTTGAACAGACGCCCGCTTTTGCGGAGTGGTTAAGGTCGTTGAAGGACTCCATTGGCAGAGCTCGAATTCT
GGCTCGAATAAGAGCAGCAGAGCTCGGTAACTTCGGGGACTGCGATGCTTTAGGTCAAGGCGTCAGAGAGCTACGAATAC
ACCATGGACCAGGTTATCGGGTGTATTTTGCCCGACGCACGGGTGTGGTTTACCTGCTCTTGATCGCTGGTGACAAATCG
TCTCAAAAGCGCGACATAAAATTTGCCAGACAGCTGGCGAGAGAGCTCTGTGAGAGGGAGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12041.89 Da        Isoelectric Point: 10.1317

>AT168257 WP_115764773.1 NZ_CP059091:69871-70185 [Pantoea agglomerans]
MTERDIFSELMTGMQELKDHQEGKITLKSYKVTKRAPVTIAPQELRDVREKLNLSQAVFARYLHTGETTYQNWEQGRARP
NAQAVLLIRMVQQNPETLKTLAKL

Download         Length: 315 bp

>AT168257 NZ_CP075686:5289328-5289618 [Pseudomonas amygdali pv. lachrymans]
ATGAACAACGAGACGACACCGTTCGATACCGTCGACTATTTGAAGACACCTGAAGATATGGCCAATTATCTGGATGCGTG
TCTTGAAGAGGATTCAGGAGACGGGCTGCTCGTAAGGGCCGCGCTGAACGACATAGCAAGGGCTTATGGCATGACACAAA
TCGCACGTGATACAGGTCTTGGTCGTGAGAGCCTCTACAAAGCGCTGGGTGCAAACGGTAATCCAGAGTTCACGACCATC
ATGAAAGTCGTGAGGGCGATGGGGATCAAACTACACGCAAGTACGCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References