Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3867083..3867728 Replicon chromosome
Accession NZ_CP059089
Organism Pantoea agglomerans strain AR1a

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H0Z11_RS19150 Protein ID WP_208002547.1
Coordinates 3867375..3867728 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H0Z11_RS19145 Protein ID WP_208002546.1
Coordinates 3867083..3867382 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0Z11_RS19130 (H0Z11_19120) 3862993..3864777 - 1785 WP_208002545.1 GMC family oxidoreductase -
H0Z11_RS19135 (H0Z11_19125) 3864780..3865514 - 735 WP_033787533.1 gluconate 2-dehydrogenase subunit 3 family protein -
H0Z11_RS19140 (H0Z11_19130) 3865791..3867035 + 1245 WP_010252115.1 peptide antibiotic transporter SbmA -
H0Z11_RS19145 (H0Z11_19135) 3867083..3867382 - 300 WP_208002546.1 helix-turn-helix transcriptional regulator Antitoxin
H0Z11_RS19150 (H0Z11_19140) 3867375..3867728 - 354 WP_208002547.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H0Z11_RS19155 (H0Z11_19145) 3867938..3868990 - 1053 WP_208002548.1 YncE family protein -
H0Z11_RS19160 (H0Z11_19150) 3869193..3869402 - 210 WP_009092571.1 DUF1471 domain-containing protein -
H0Z11_RS19165 (H0Z11_19155) 3869615..3870802 - 1188 WP_064704970.1 MFS transporter -
H0Z11_RS19170 (H0Z11_19160) 3870907..3871872 + 966 WP_010252125.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13362.28 Da        Isoelectric Point: 6.4723

>T168256 WP_208002547.1 NZ_CP059089:c3867728-3867375 [Pantoea agglomerans]
MWDVDTTKRFDEWFKAQTEELKEDMLAAIVILSEYGPHLARPFADTVDGSDFPNMKELRVQHQGIPIRAFFAFAPSRRGI
VLCAGDKTGVKEKKFYKDMIKLADAEFRKYLNGGDNG

Download         Length: 354 bp

>T168256 NZ_CP075686:4386253-4386537 [Pseudomonas amygdali pv. lachrymans]
ATGCAGGTTGAGTGGCTTAAAACGGCGCTAAAGAATCTGGATGAGGAGGCAGCGTATATCGCACAGGACAATCCAGCTGC
TGCCGCAGCTTTCGTGAAAGCAATTCAATCAAGCGTGACGCAGCTCGCGAGCTTTCCCGCCATGGGCCGGGAAGGACGGA
TTGCCGGAACCAGAGAATGGCCTCTGCCAGACCTGCCTTACCTGATTCCATATCGCATCCGTAGCGGCCGGCTACAGGTT
CTAAGGATTTTCCACACCAGAAGACAATCGCCCCCCGTGTGGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11150.02 Da        Isoelectric Point: 9.8103

>AT168256 WP_208002546.1 NZ_CP059089:c3867382-3867083 [Pantoea agglomerans]
MANLKEMMANQSPESRERIAKKVDAMRQVIALHMLREELNLSQTEMAHAMGVKQPTIARMEQADNDPRLSTLKRYVTALG
GEISIDVKLPTGKRIAFDL

Download         Length: 300 bp

>AT168256 NZ_CP075686:4386024-4386263 [Pseudomonas amygdali pv. lachrymans]
ATGTCCACAATGTCTCTACGTCTGCCGGACGAAATGGCGGATACCCTTGCACACCTTGCAAAGGCGACCGGGCGCAGCAA
GTCATTTTTGGCCCTCGACGCGCTCCGCGAATACCTGACTCGCGAGGCATGGCAGATTGCCGAAATTCAGCGCGCGATTG
AAGAAGCCGACGCTGGCGAGTTCGCCAATACAGAGGACGTAAAAGCTGTCATGGACAAATGGTCTGGCAATGCAGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References