Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 24048..24639 Replicon plasmid pAR1aB
Accession NZ_CP059088
Organism Pantoea agglomerans strain AR1a

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H0Z11_RS00560 Protein ID WP_207874175.1
Coordinates 24319..24639 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H0Z11_RS00555 Protein ID WP_205317936.1
Coordinates 24048..24329 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0Z11_RS00535 (H0Z11_00535) 19403..21730 - 2328 WP_207874173.1 FdhF/YdeP family oxidoreductase -
H0Z11_RS00540 (H0Z11_00540) 22299..22706 - 408 WP_137229086.1 type II toxin-antitoxin system HicB family antitoxin -
H0Z11_RS00545 (H0Z11_00545) 22777..22950 - 174 WP_137229084.1 type II toxin-antitoxin system HicA family toxin -
H0Z11_RS00550 (H0Z11_00550) 23580..23927 - 348 WP_003850685.1 HNH nuclease YajD -
H0Z11_RS00555 (H0Z11_00555) 24048..24329 - 282 WP_205317936.1 helix-turn-helix transcriptional regulator Antitoxin
H0Z11_RS00560 (H0Z11_00560) 24319..24639 - 321 WP_207874175.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H0Z11_RS00565 (H0Z11_00565) 24963..25130 - 168 WP_009093121.1 hypothetical protein -
H0Z11_RS00570 (H0Z11_00570) 25421..28525 + 3105 WP_207874177.1 efflux RND transporter permease subunit -
H0Z11_RS00575 (H0Z11_00575) 28585..29610 - 1026 WP_207874179.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..160336 160336


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-88)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12059.12 Da        Isoelectric Point: 8.0410

>T168246 WP_207874175.1 NZ_CP059088:c24639-24319 [Pantoea agglomerans]
MFTVKFHDDAGDELEVLPADIAAKMVRLLEKLQENPRSLREPHCKPLGNGLFEVRTMGGDIARGLWVYQTGKNIFVLRIF
MKKTSKTPLAEINLAFRRLEEMLDGA

Download         Length: 321 bp

>T168246 NZ_CP075666:14264-14545 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGCAGGGCACTGAAGGAATGGCAGAAGCTGGGCCACACCATCCGCGAACAATTCAA
AAAGAAACTGTCTGAACGCCTGGAAAATCCACGCGTGCCTGCATCCAGGTTACATGGTCATGCTGACCGTTACAAAATCA
AACTTCGTACATCTGGTTACAGACTTGTATATCAAGTCATTGATGAAAAAGTTGTTTTACTCGTTATTTCCGTTGGAAAA
AGGGAAGGTAACGAAGTTTATCAGATCGCAGATATGCGCTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10243.75 Da        Isoelectric Point: 10.0993

>AT168246 WP_205317936.1 NZ_CP059088:c24329-24048 [Pantoea agglomerans]
MAHKTLAELKARLMQRDDFQAAYEAEARKERLQALLAEWRSHAGLNSADVAARMGIAPSTLSRMEKNITSASVENLSKYA
RACGVKAATLFFS

Download         Length: 282 bp

>AT168246 NZ_CP075666:14023-14274 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACTACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
CGAGGGAGACGCAGTTGTGATCCTGAACCGAAACGAACCAGCGTTCTACTGCGTCCCCCCAAAACTTTACGCCTATTATC
GGGAACTCGCTGAAGATGCCGAATTAAACGCTGTTGCTGATGAGCGCATGAAAAATCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References