Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1750447..1751107 Replicon chromosome
Accession NZ_CP059084
Organism Pantoea ananatis strain OC5a

Toxin (Protein)


Gene name higB Uniprot ID A0A8A4KH73
Locus tag H0Z12_RS09440 Protein ID WP_072138139.1
Coordinates 1750447..1750773 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H0Z12_RS09445 Protein ID WP_013026312.1
Coordinates 1750805..1751107 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0Z12_RS09420 (H0Z12_09415) 1746284..1747765 + 1482 WP_207806625.1 rhamnulokinase -
H0Z12_RS09425 (H0Z12_09420) 1747749..1749005 + 1257 WP_024471870.1 L-rhamnose isomerase -
H0Z12_RS09430 (H0Z12_09425) 1749016..1749858 + 843 WP_013026315.1 rhamnulose-1-phosphate aldolase -
H0Z12_RS09435 (H0Z12_09430) 1749848..1750162 + 315 WP_024471869.1 L-rhamnose mutarotase -
H0Z12_RS09440 (H0Z12_09435) 1750447..1750773 + 327 WP_072138139.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H0Z12_RS09445 (H0Z12_09440) 1750805..1751107 + 303 WP_013026312.1 XRE family transcriptional regulator Antitoxin
H0Z12_RS09455 (H0Z12_09450) 1752026..1753147 + 1122 WP_014605487.1 Gfo/Idh/MocA family oxidoreductase -
H0Z12_RS09460 (H0Z12_09455) 1753227..1754054 - 828 WP_015699982.1 glycosyltransferase family 8 protein -
H0Z12_RS09465 (H0Z12_09460) 1754056..1755453 - 1398 WP_013026309.1 D-arabinono-1,4-lactone oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12301.03 Da        Isoelectric Point: 8.4979

>T168231 WP_072138139.1 NZ_CP059084:1750447-1750773 [Pantoea ananatis]
VWPIKTTDTFDCWFTSLSDIDRADVLAALLVLREKGPGLSRPYADTLKGSRYSNMKERRIQSRDDPLRAFFAFDPARTGI
VLCAGNKVGNEKRFYDAMLPVADREFTH

Download         Length: 327 bp

>T168231 NZ_CP075665:1408242-1408349 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11059.77 Da        Isoelectric Point: 5.1679

>AT168231 WP_013026312.1 NZ_CP059084:1750805-1751107 [Pantoea ananatis]
MGRTLEQLIADEKNDVVDEAQAMATDILLNIHLAELREKVQKTQVEMAQALGIKQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Download         Length: 303 bp

>AT168231 NZ_CP075665:c1408192-1408129 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References