Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 120741..121317 Replicon chromosome
Accession NZ_CP059082
Organism Halomonas titanicae strain SOB56

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HZS52_RS00540 Protein ID WP_138800920.1
Coordinates 121039..121317 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag HZS52_RS00535 Protein ID WP_022520034.1
Coordinates 120741..121028 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS52_RS00515 116535..117728 + 1194 WP_190373973.1 homoserine O-acetyltransferase -
HZS52_RS00520 117828..118481 - 654 WP_190373974.1 DsbA family oxidoreductase -
HZS52_RS00525 119146..119667 + 522 WP_190373975.1 NAD(P)H-dependent oxidoreductase -
HZS52_RS00530 120215..120634 + 420 WP_022520033.1 hypothetical protein -
HZS52_RS00535 120741..121028 - 288 WP_022520034.1 HigA family addiction module antidote protein Antitoxin
HZS52_RS00540 121039..121317 - 279 WP_138800920.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZS52_RS00545 121427..122389 - 963 WP_190373976.1 ribonuclease Z -
HZS52_RS00550 122618..123025 - 408 WP_190373977.1 GFA family protein -
HZS52_RS00555 123136..123834 - 699 WP_190373978.1 class I SAM-dependent methyltransferase -
HZS52_RS00560 123906..124760 - 855 WP_141439979.1 Dimeric alpha-beta barrel -
HZS52_RS00565 125164..126009 - 846 WP_141439980.1 EamA family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 119146..130310 11164


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-86)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10304.71 Da        Isoelectric Point: 10.3742

>T168218 WP_138800920.1 NZ_CP059082:c121317-121039 [Halomonas titanicae]
MIRSFKHKGLAKFFKSGSTAGIQAAHAKRLRLILGRLNAASDANDMDLPGLRLHELSGKRSGIWSVTVSGNWRVTFRFED
GDAEIVNYEDYH

Download         Length: 279 bp

>T168218 NZ_CP075663:c4005063-4004686 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AATGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10442.08 Da        Isoelectric Point: 7.3596

>AT168218 WP_022520034.1 NZ_CP059082:c121028-120741 [Halomonas titanicae]
MLMHNPPHPGEVLRELCLEPLGLTVTAAAEALGVSRKTLSAVLNGKAGISPEMAVRLSIAFDTSAESWLNQQSQYELWHA
EQHRKELKVKRLVAA

Download         Length: 288 bp

>AT168218 NZ_CP075663:c4005484-4005110 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGAAATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGGCACAGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References