Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 832008..832674 Replicon chromosome
Accession NZ_CP059068
Organism Rhodoferax sp. AJA081-3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HZ993_RS03870 Protein ID WP_209395958.1
Coordinates 832342..832674 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HZ993_RS03865 Protein ID WP_209395957.1
Coordinates 832008..832355 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZ993_RS03845 (HZ993_03850) 827410..829641 - 2232 WP_209395953.1 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase -
HZ993_RS03850 (HZ993_03855) 829663..830565 - 903 WP_209395954.1 alpha/beta hydrolase -
HZ993_RS03855 (HZ993_03860) 830666..831442 + 777 WP_209395955.1 3-hydroxybutyrate dehydrogenase -
HZ993_RS03860 (HZ993_03865) 831548..832021 - 474 WP_209395956.1 hypothetical protein -
HZ993_RS03865 (HZ993_03870) 832008..832355 - 348 WP_209395957.1 helix-turn-helix transcriptional regulator Antitoxin
HZ993_RS03870 (HZ993_03875) 832342..832674 - 333 WP_209395958.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZ993_RS24275 833423..833527 + 105 Protein_766 hypothetical protein -
HZ993_RS03885 (HZ993_03890) 833528..834061 - 534 WP_209395960.1 nucleotidyltransferase family protein -
HZ993_RS03890 (HZ993_03895) 834031..835053 - 1023 WP_209395961.1 XdhC family protein -
HZ993_RS03895 (HZ993_03900) 835062..837332 - 2271 WP_209395962.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-88)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12949.36 Da        Isoelectric Point: 10.1866

>T168203 WP_209395958.1 NZ_CP059068:c832674-832342 [Rhodoferax sp. AJA081-3]
MKWEIKYHDEKLQADVLALPPGILARYFHCTDRMVEFGPDLGMPHTRAMSMGLFELRLKSREGIGRVFYCTLVDRKIVML
HQFVKKTDKTPPKELALARKRMKEWKNVDT

Download         Length: 333 bp

>T168203 NZ_CP075654:94035-94316 [Escherichia coli]
ATGACTTATGAACTGGAATTTGAGCGCAGGGCCCTGAAAGAATGGCATAAGCTCGGTCATACAGTCCGTGAGCAGTTCAA
AAAGAAACTGTCAGAACGCCTGAAAAATCCAAGGGTCCCTGCTGCCAGGCTACATGGTCATACTGACCGTTATAAAATCA
AGCTTCGTGCATCTGGTTACAGGCTCGTCTATCAGGTGATTGATGAGAAAATTGTTTTGCTCGTTATTGCTGTAGGAAAA
AGGGAAAGCAGTGAGGTCTACCAGATGGCTGATATTCGCTGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 12423.30 Da        Isoelectric Point: 10.7542

>AT168203 WP_209395957.1 NZ_CP059068:c832355-832008 [Rhodoferax sp. AJA081-3]
MLTHKQLRTKALATAEVKAEYEKLADEFSLLDEFLKARAAQGLTQAQVAEKIGTTQSAVARMESGSGKHSPSLATLTKYA
DALGCKLEVRLVRRPRSTKNATGRPSPTTPKRVAA

Download         Length: 348 bp

>AT168203 NZ_CP075654:93794-94045 [Escherichia coli]
ATGAGTTACCAGATTTTGACCACGACAGCAGCAAGTATTACTGAGCTGAAAAAAAATCCTATGGGCACGGTAGCCGAAGG
TGAAGGAGGGGCCGTTGCAATCCTGAACCGAAATGAGCCTGCGTTCTACTGTGTCCCTCCGGAACTTTATGCCTACTACC
GGGAGCTCGCCGAAGATGCTGAGCTAAACGCAATTGCTGATGAAAGAATGAAGAATCCGGACATTGTGAAGGTTAGTCTG
GATGACTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References