Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 919634..920214 Replicon chromosome
Accession NZ_CP059060
Organism Synechococcus sp. LTW-R

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag H0O22_RS05215 Protein ID WP_185187915.1
Coordinates 919634..919912 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H0O22_RS05220 Protein ID WP_185187916.1
Coordinates 919912..920214 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0O22_RS05195 915363..916724 + 1362 WP_185187911.1 glutathione-disulfide reductase -
H0O22_RS05200 916729..917436 + 708 WP_185187912.1 SDR family NAD(P)-dependent oxidoreductase -
H0O22_RS05205 917433..918764 - 1332 WP_185187913.1 sodium:alanine symporter family protein -
H0O22_RS05210 918814..919491 - 678 WP_185187914.1 DUF3386 domain-containing protein -
H0O22_RS05215 919634..919912 + 279 WP_185187915.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H0O22_RS05220 919912..920214 + 303 WP_185187916.1 HigA family addiction module antidote protein Antitoxin
H0O22_RS05225 920219..923512 - 3294 WP_185187917.1 carbamoyl-phosphate synthase large subunit -
H0O22_RS05230 923640..924275 + 636 WP_185187918.1 DUF3318 domain-containing protein -
H0O22_RS05235 924268..924681 + 414 WP_185187919.1 ribosome silencing factor -
H0O22_RS05240 924694..925206 + 513 WP_185187920.1 CGLD27 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(25-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-71)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10757.23 Da        Isoelectric Point: 8.5613

>T168196 WP_185187915.1 NZ_CP059060:919634-919912 [Synechococcus sp. LTW-R]
VIRSFRCADTERLAHGWAIPRFQAFERVARRKLRQLDIASRLEDLRIPPGNRLEALRGDRAGEHSIRINDQFRLCFIWSD
SGPEAVEIVDYH

Download         Length: 279 bp

>T168196 NZ_CP075652:4774347-4774450 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10910.59 Da        Isoelectric Point: 5.8146

>AT168196 WP_185187916.1 NZ_CP059060:919912-920214 [Synechococcus sp. LTW-R]
MTATHRLSPITPGELLVEEFLVPLGVSQYRLSKAIKVPASRISEIVSGQRSITADTDLRLCRFLGLSPGYWLRAQAAYDT
EIAGAELAEEIAKIQPLVNS

Download         Length: 303 bp

>AT168196 NZ_CP075652:c4774488-4774217 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References