Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2844849..2845496 Replicon chromosome
Accession NZ_CP059045
Organism Cronobacter sakazakii strain 5563_17

Toxin (Protein)


Gene name higB Uniprot ID A0A6L3S314
Locus tag HZZ03_RS13360 Protein ID WP_012124279.1
Coordinates 2845149..2845496 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID V5TYW5
Locus tag HZZ03_RS13355 Protein ID WP_007776551.1
Coordinates 2844849..2845148 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZZ03_RS13325 2840259..2840825 + 567 WP_012124285.1 DedA family protein -
HZZ03_RS13330 2840822..2841595 - 774 WP_012124284.1 SDR family oxidoreductase -
HZZ03_RS13335 2841768..2841851 + 84 WP_000691708.1 protein YohP -
HZZ03_RS13340 2841888..2842847 - 960 WP_012124283.1 MBL fold metallo-hydrolase -
HZZ03_RS13345 2842920..2843843 + 924 WP_012124282.1 LysR family transcriptional regulator -
HZZ03_RS13350 2843846..2844778 - 933 WP_012124281.1 tRNA dihydrouridine(16) synthase DusC -
HZZ03_RS13355 2844849..2845148 - 300 WP_007776551.1 XRE family transcriptional regulator Antitoxin
HZZ03_RS13360 2845149..2845496 - 348 WP_012124279.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZZ03_RS13365 2845749..2846150 + 402 WP_007869367.1 CidA/LrgA family protein -
HZZ03_RS13370 2846147..2846842 + 696 WP_007869369.1 CidB/LrgB family autolysis modulator -
HZZ03_RS13375 2846972..2847856 + 885 WP_012124277.1 cytidine deaminase -
HZZ03_RS13380 2847981..2848694 + 714 WP_004387784.1 outer membrane permeability protein SanA -
HZZ03_RS13385 2849410..2850420 - 1011 WP_004387466.1 galactose/methyl galactoside ABC transporter permease MglC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-83)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13397.61 Da        Isoelectric Point: 9.8777

>T168171 WP_012124279.1 NZ_CP059045:c2845496-2845149 [Cronobacter sakazakii]
MWTIYLTHEFECWLARQPQPLQEDVLTALGLLKIKGPHLGCPYADTLKGSRQAGMKELRVQHAGRSIRAFYAFDPHRYAI
VLCAAQKKGDEKRFYRVILRVADKLFSHYLNHREV

Download         Length: 348 bp

>T168171 NZ_CP075649:c4605622-4605248 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCGCGTCCGTCTCCTGTTGAAATCTGGCAGACACTGCTGTC
CCGCCTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCTCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCCCGGTTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11035.67 Da        Isoelectric Point: 5.1667

>AT168171 WP_007776551.1 NZ_CP059045:c2845148-2844849 [Cronobacter sakazakii]
MKTFDEVLAAQTPEARARIEEKTAQLLLETHLYALREALSVSQTEMARQMGIAQPSVAAIEQRGNEMKISTLKRYVEALG
GTVRLDVELPDGQRFGFTL

Download         Length: 300 bp

>AT168171 NZ_CP075649:c4606080-4605712 [Escherichia coli]
GTGTCAGACACGCACCATGAGACAAATTATCCCGACGACTATAACAACCGCCCCTGGTGGGGGCTGCCCTGCACCATAAC
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGTATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATACTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGACTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L3S314

Antitoxin

Source ID Structure
AlphaFold DB A0A2S9UA72

References