Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2789170..2789815 Replicon chromosome
Accession NZ_CP059045
Organism Cronobacter sakazakii strain 5563_17

Toxin (Protein)


Gene name higB Uniprot ID A0A6L3QTA3
Locus tag HZZ03_RS13115 Protein ID WP_004388208.1
Coordinates 2789453..2789815 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6L3TU83
Locus tag HZZ03_RS13110 Protein ID WP_004388209.1
Coordinates 2789170..2789466 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZZ03_RS13100 2786824..2787672 - 849 WP_180552771.1 DNA-3-methyladenine glycosylase 2 -
HZZ03_RS13105 2787808..2789160 + 1353 WP_012124316.1 molecular chaperone -
HZZ03_RS13110 2789170..2789466 - 297 WP_004388209.1 XRE family transcriptional regulator Antitoxin
HZZ03_RS13115 2789453..2789815 - 363 WP_004388208.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZZ03_RS13120 2790046..2791293 + 1248 WP_004388207.1 MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit -
HZZ03_RS13125 2791293..2794415 + 3123 WP_012124312.1 MdtB/MuxB family multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-86)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14197.07 Da        Isoelectric Point: 8.0154

>T168170 WP_004388208.1 NZ_CP059045:c2789815-2789453 [Cronobacter sakazakii]
MAWTVIFTDRFNDWYQQQPEGLQDRIAALLWNLRYSGPLVGRPLVDTVKGSRYPNLKELRVQYGGEPWRVFFAFDAERQA
VVLCAGNKRSQKHFYDALIRQAEEEFFLHVQAMERRNENS

Download         Length: 363 bp

>T168170 NZ_CP075649:c4502820-4502470 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10837.75 Da        Isoelectric Point: 5.8787

>AT168170 WP_004388209.1 NZ_CP059045:c2789466-2789170 [Cronobacter sakazakii]
MKTLDDVMAGFSPERQAEILRMADEIALEHGLPRIREARAFSQQQLAEIMGVTQPAIAAIEQRGKEIKLLTLKRYVEALG
GKLSLLIELPEGSKVIPV

Download         Length: 297 bp

>AT168170 NZ_CP075649:c4503065-4502814 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L3QTA3

Antitoxin

Source ID Structure
AlphaFold DB A0A6L3TU83

References