168141

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2521471..2521973 Replicon chromosome
Accession NZ_CP059043
Organism Escherichia coli strain SY3626C1

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag HZ987_RS12400 Protein ID WP_000767829.1
Coordinates 2521471..2521725 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HZ987_RS12405 Protein ID WP_001259255.1
Coordinates 2521722..2521973 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZ987_RS12370 2516486..2516713 - 228 WP_000234896.1 sulfurtransferase TusA -
HZ987_RS12375 2516727..2517785 - 1059 WP_000492339.1 transport protein YeeE -
HZ987_RS12380 2517964..2519322 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
HZ987_RS12385 2519312..2519374 - 63 WP_010723108.1 membrane protein YoeI -
HZ987_RS12390 2519589..2520518 - 930 WP_000803351.1 LysR family transcriptional regulator -
HZ987_RS12395 2520564..2521388 - 825 WP_000754737.1 SDR family oxidoreductase -
HZ987_RS12400 2521471..2521725 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HZ987_RS12405 2521722..2521973 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HZ987_RS12410 2522256..2522306 + 51 WP_001364200.1 his operon leader peptide -
HZ987_RS12415 2522452..2523351 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
HZ987_RS12420 2523357..2524661 + 1305 WP_000009594.1 histidinol dehydrogenase -
HZ987_RS12425 2524658..2525728 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
HZ987_RS12430 2525728..2526795 + 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T168141 WP_000767829.1 NZ_CP059043:c2521725-2521471 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T168141 NZ_CP075642:5417-5701 [Escherichia coli]
ATGAATGGTGGGCTAAAAAAATTTGATGTTGTTGAGTATCTGGAAGATGAAGAAGATATTCAGGCGTATCTGAATGCAGC
CATTGAAGAGGGAGATACTAAATATTTCTTTAAAGCACTTGGAAACATAGCCAGAGCAAGAAATATCAGCCAGCTATCTA
AAGATGCAGGAATGTCGAGAGAAGGGATATATAAGGCGTTATCCGGTGAAGGTAATCCGTCATTCAACACGGTTGCCAGA
ATAACTAAGGCACTTGGCCTGAAACTTCAATTCAAAGGGGCCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT168141 WP_001259255.1 NZ_CP059043:c2521973-2521722 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT168141 NZ_CP075642:5119-5415 [Escherichia coli]
ATGATAGAAATGAAACAGACACCAGAGTTTGAAAAATGGTTAAAGTCTCTAAAAGACAAAATAGCAAAAGCTAAAATATT
GATGCGCCTCGAACGCATGGAGGAAGGAAACTTCGGTGATGTTGAACCTGTAGGAGATGGATTATCAGAATTAAGGATTC
ATCAGGGGAAAGGCTACCGGATATATTTTGGAAATAAAAATAATCAGATTGTTATTTTACTGTGTGGTGGTGATAAAAGC
ACACAACAGTTGGATATTAAGAAGGCAAAAATTTTAGCGAAAAAATGGGGATTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References