Detailed information of TA system TA168109

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 183528..183750
• Replicon: chromosome
• Accession: NZ_CP059043
• Organism: Escherichia coli strain SY3626C1

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: HZ987_RS00865
• Protein ID: WP_000141634.1
• Coordinates: 183643..183750 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	183528..183594 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZ987_RS00845	178969..179871	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
HZ987_RS00850	179882..180865	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
HZ987_RS00855	180862..181866	+	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
HZ987_RS00860	181896..183167	-	1272	WP_001295225.1	transporter	-
-	183528..183594	-	67	-	-	Antitoxin
HZ987_RS00865	183643..183750	+	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
HZ987_RS00870	183837..185516	-	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
HZ987_RS00875	185513..185704	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
HZ987_RS00880	185701..187272	-	1572	WP_001204931.1	cellulose biosynthesis protein BcsE	-
HZ987_RS00885	187545..187733	+	189	WP_001063318.1	YhjR family protein	-
HZ987_RS00890	187745..188497	+	753	Protein_174	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T168109 WP_000141634.1 NZ_CP059043:183643-183750 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T168109 NZ_CP075633:c82925-82509 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT168109 NZ_CP059043:c183594-183528 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin