Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1800271..1801045 Replicon chromosome
Accession NZ_CP059035
Organism Pasteurella multocida subsp. multocida strain HN141014

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A0R66_RS08270 Protein ID WP_061406326.1
Coordinates 1800271..1800597 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A0R66_RS08275 Protein ID WP_005757699.1
Coordinates 1800719..1801045 (+) Length 109 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A0R66_RS08245 (A0R66_008225) 1795588..1796274 + 687 WP_061406323.1 hypothetical protein -
A0R66_RS08250 (A0R66_008230) 1796328..1797857 - 1530 WP_061406324.1 YifB family Mg chelatase-like AAA ATPase -
A0R66_RS08255 (A0R66_008235) 1797966..1798583 - 618 WP_005724253.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
A0R66_RS08260 (A0R66_008240) 1798694..1799563 + 870 WP_061406325.1 VirK/YbjX family protein -
A0R66_RS08265 (A0R66_008245) 1799637..1800113 - 477 WP_042742721.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
A0R66_RS08270 (A0R66_008250) 1800271..1800597 + 327 WP_061406326.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A0R66_RS08275 (A0R66_008255) 1800719..1801045 + 327 WP_005757699.1 HigA family addiction module antitoxin Antitoxin
A0R66_RS08280 (A0R66_008260) 1801100..1802620 - 1521 WP_061406327.1 surface lipoprotein assembly modifier -
A0R66_RS08285 (A0R66_008265) 1802679..1803269 - 591 WP_061406438.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
A0R66_RS08290 (A0R66_008270) 1803332..1804342 - 1011 WP_061406328.1 hypothetical protein -
A0R66_RS08295 (A0R66_008275) 1804578..1805609 - 1032 WP_061406329.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-104)

Antitoxin

(1-102)


Sequences


Toxin        


Download         Length: 109 a.a.        Molecular weight: 12923.75 Da        Isoelectric Point: 9.6705

>T168100 WP_061406326.1 NZ_CP059035:1800271-1800597 [Pasteurella multocida subsp. multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSQPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL

Download         Length: 327 bp

>T168100 NZ_CP075632:c3531495-3531118 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGTCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12377.41 Da        Isoelectric Point: 7.2034

>AT168100 WP_005757699.1 NZ_CP059035:1800719-1801045 [Pasteurella multocida subsp. multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA

Download         Length: 327 bp

>AT168100 NZ_CP075632:c3531919-3531542 [Escherichia coli]
GTGTCAGACACACTCCCCGGAACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCGGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTAGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References