Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 1800271..1801045 | Replicon | chromosome |
Accession | NZ_CP059035 | ||
Organism | Pasteurella multocida subsp. multocida strain HN141014 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | A0R66_RS08270 | Protein ID | WP_061406326.1 |
Coordinates | 1800271..1800597 (+) | Length | 109 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | A0R66_RS08275 | Protein ID | WP_005757699.1 |
Coordinates | 1800719..1801045 (+) | Length | 109 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
A0R66_RS08245 (A0R66_008225) | 1795588..1796274 | + | 687 | WP_061406323.1 | hypothetical protein | - |
A0R66_RS08250 (A0R66_008230) | 1796328..1797857 | - | 1530 | WP_061406324.1 | YifB family Mg chelatase-like AAA ATPase | - |
A0R66_RS08255 (A0R66_008235) | 1797966..1798583 | - | 618 | WP_005724253.1 | ribosome biogenesis GTP-binding protein YihA/YsxC | - |
A0R66_RS08260 (A0R66_008240) | 1798694..1799563 | + | 870 | WP_061406325.1 | VirK/YbjX family protein | - |
A0R66_RS08265 (A0R66_008245) | 1799637..1800113 | - | 477 | WP_042742721.1 | tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL | - |
A0R66_RS08270 (A0R66_008250) | 1800271..1800597 | + | 327 | WP_061406326.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
A0R66_RS08275 (A0R66_008255) | 1800719..1801045 | + | 327 | WP_005757699.1 | HigA family addiction module antitoxin | Antitoxin |
A0R66_RS08280 (A0R66_008260) | 1801100..1802620 | - | 1521 | WP_061406327.1 | surface lipoprotein assembly modifier | - |
A0R66_RS08285 (A0R66_008265) | 1802679..1803269 | - | 591 | WP_061406438.1 | 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD | - |
A0R66_RS08290 (A0R66_008270) | 1803332..1804342 | - | 1011 | WP_061406328.1 | hypothetical protein | - |
A0R66_RS08295 (A0R66_008275) | 1804578..1805609 | - | 1032 | WP_061406329.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 109 a.a. Molecular weight: 12923.75 Da Isoelectric Point: 9.6705
>T168100 WP_061406326.1 NZ_CP059035:1800271-1800597 [Pasteurella multocida subsp. multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSQPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSQPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL
Download Length: 327 bp
>T168100 NZ_CP075632:c3531495-3531118 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGTCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGTCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 109 a.a. Molecular weight: 12377.41 Da Isoelectric Point: 7.2034
>AT168100 WP_005757699.1 NZ_CP059035:1800719-1801045 [Pasteurella multocida subsp. multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA
Download Length: 327 bp
>AT168100 NZ_CP075632:c3531919-3531542 [Escherichia coli]
GTGTCAGACACACTCCCCGGAACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCGGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTAGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA
GTGTCAGACACACTCCCCGGAACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCGGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTAGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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