Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3604003..3604696 Replicon chromosome
Accession NZ_CP058948
Organism Escherichia coli strain SY3626C5

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HZ988_RS17445 Protein ID WP_000415584.1
Coordinates 3604400..3604696 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HZ988_RS17440 Protein ID WP_000650107.1
Coordinates 3604003..3604398 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZ988_RS17430 3599867..3602125 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
HZ988_RS17435 3602263..3603870 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HZ988_RS17440 3604003..3604398 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HZ988_RS17445 3604400..3604696 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HZ988_RS17450 3604901..3605383 - 483 WP_000183505.1 transcriptional regulator -
HZ988_RS17455 3605436..3605828 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HZ988_RS17460 3605980..3606639 + 660 WP_001221495.1 two-component system response regulator QseB -
HZ988_RS17465 3606636..3607985 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
HZ988_RS17470 3608031..3608363 - 333 WP_000917684.1 DUF2645 family protein -
HZ988_RS17475 3608682..3609263 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HZ988_RS17480 3609294..3609608 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T168018 WP_000415584.1 NZ_CP058948:c3604696-3604400 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T168018 NZ_CP075566:c783297-783118 [Pseudomonas fluorescens]
GTGAATAGCCGATTTTTGATAAGCCAAATTGTTGCGGATGGCTGGTATCTGGTGCGTATCAAGGGCAGTCATCATCACTT
CAAGCACCCGACCAAACCGGGGCTGGTGACAGTTCCTCATCCAAAAAAGGACCTGCTCAAAAAAACGGCCTTGAGTATTT
TGCAACAGGCGCTGCTCTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT168018 WP_000650107.1 NZ_CP058948:c3604398-3604003 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT168018 NZ_CP075566:c783081-782674 [Pseudomonas fluorescens]
ATGCTTTACCCGATTGCGATTTCAATGGGCGATAACGAACACGCTTGGGGCGTAGAAGTACCGGATATTCCAGGGTGTTT
CTCTGCAGGTGAGGATCTTGATGATGCGATGGCCATGGCTCGTGAAGCCATTGAGGGCCATTTCGAAATTCTTGCCGAAG
ACGGTTCACCGATTCCACCTGCAAACAAAGTCACTTTGCATGCGGCCAATCCGCATTACGCAGGTTGCACATGGGCGGTG
GTGGACATCGATGTTACCAAGTACCTGGGCAAAGCCCAGAAGCTGAACATCACCCTGCCGGGGTACCTGCTCAACCGCAT
CGACGAATACGTATTGCATCACCCGGAAGAGAAAAGCCGTTCAGGTTTTCTGGCATCGGCAGCACTGAAGGTGTTGCAGG
AGAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References