Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mqsRA (relBE)/MqsR-MqsA |
Location | 3604003..3604696 | Replicon | chromosome |
Accession | NZ_CP058948 | ||
Organism | Escherichia coli strain SY3626C5 |
Toxin (Protein)
Gene name | mqsR | Uniprot ID | S1EZG2 |
Locus tag | HZ988_RS17445 | Protein ID | WP_000415584.1 |
Coordinates | 3604400..3604696 (-) | Length | 99 a.a. |
Antitoxin (Protein)
Gene name | mqsA | Uniprot ID | S1EBV2 |
Locus tag | HZ988_RS17440 | Protein ID | WP_000650107.1 |
Coordinates | 3604003..3604398 (-) | Length | 132 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HZ988_RS17430 | 3599867..3602125 | - | 2259 | WP_001281881.1 | DNA topoisomerase IV subunit A | - |
HZ988_RS17435 | 3602263..3603870 | - | 1608 | WP_001295629.1 | ABC transporter substrate-binding protein | - |
HZ988_RS17440 | 3604003..3604398 | - | 396 | WP_000650107.1 | type II toxin-antitoxin system antitoxin MqsA | Antitoxin |
HZ988_RS17445 | 3604400..3604696 | - | 297 | WP_000415584.1 | type II toxin-antitoxin system toxin MqsR | Toxin |
HZ988_RS17450 | 3604901..3605383 | - | 483 | WP_000183505.1 | transcriptional regulator | - |
HZ988_RS17455 | 3605436..3605828 | - | 393 | WP_000712658.1 | OB fold stress tolerance protein YgiW | - |
HZ988_RS17460 | 3605980..3606639 | + | 660 | WP_001221495.1 | two-component system response regulator QseB | - |
HZ988_RS17465 | 3606636..3607985 | + | 1350 | WP_000673402.1 | two-component system sensor histidine kinase QseC | - |
HZ988_RS17470 | 3608031..3608363 | - | 333 | WP_000917684.1 | DUF2645 family protein | - |
HZ988_RS17475 | 3608682..3609263 | + | 582 | WP_000065430.1 | NADPH:quinone oxidoreductase MdaB | - |
HZ988_RS17480 | 3609294..3609608 | + | 315 | WP_000958598.1 | antibiotic biosynthesis monooxygenase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11231.96 Da Isoelectric Point: 8.9070
>T168018 WP_000415584.1 NZ_CP058948:c3604696-3604400 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK
Download Length: 297 bp
>T168018 NZ_CP075566:c783297-783118 [Pseudomonas fluorescens]
GTGAATAGCCGATTTTTGATAAGCCAAATTGTTGCGGATGGCTGGTATCTGGTGCGTATCAAGGGCAGTCATCATCACTT
CAAGCACCCGACCAAACCGGGGCTGGTGACAGTTCCTCATCCAAAAAAGGACCTGCTCAAAAAAACGGCCTTGAGTATTT
TGCAACAGGCGCTGCTCTGA
GTGAATAGCCGATTTTTGATAAGCCAAATTGTTGCGGATGGCTGGTATCTGGTGCGTATCAAGGGCAGTCATCATCACTT
CAAGCACCCGACCAAACCGGGGCTGGTGACAGTTCCTCATCCAAAAAAGGACCTGCTCAAAAAAACGGCCTTGAGTATTT
TGCAACAGGCGCTGCTCTGA
Antitoxin
Download Length: 132 a.a. Molecular weight: 14703.10 Da Isoelectric Point: 9.2136
>AT168018 WP_000650107.1 NZ_CP058948:c3604398-3604003 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR
Download Length: 396 bp
>AT168018 NZ_CP075566:c783081-782674 [Pseudomonas fluorescens]
ATGCTTTACCCGATTGCGATTTCAATGGGCGATAACGAACACGCTTGGGGCGTAGAAGTACCGGATATTCCAGGGTGTTT
CTCTGCAGGTGAGGATCTTGATGATGCGATGGCCATGGCTCGTGAAGCCATTGAGGGCCATTTCGAAATTCTTGCCGAAG
ACGGTTCACCGATTCCACCTGCAAACAAAGTCACTTTGCATGCGGCCAATCCGCATTACGCAGGTTGCACATGGGCGGTG
GTGGACATCGATGTTACCAAGTACCTGGGCAAAGCCCAGAAGCTGAACATCACCCTGCCGGGGTACCTGCTCAACCGCAT
CGACGAATACGTATTGCATCACCCGGAAGAGAAAAGCCGTTCAGGTTTTCTGGCATCGGCAGCACTGAAGGTGTTGCAGG
AGAGCTGA
ATGCTTTACCCGATTGCGATTTCAATGGGCGATAACGAACACGCTTGGGGCGTAGAAGTACCGGATATTCCAGGGTGTTT
CTCTGCAGGTGAGGATCTTGATGATGCGATGGCCATGGCTCGTGAAGCCATTGAGGGCCATTTCGAAATTCTTGCCGAAG
ACGGTTCACCGATTCCACCTGCAAACAAAGTCACTTTGCATGCGGCCAATCCGCATTACGCAGGTTGCACATGGGCGGTG
GTGGACATCGATGTTACCAAGTACCTGGGCAAAGCCCAGAAGCTGAACATCACCCTGCCGGGGTACCTGCTCAACCGCAT
CGACGAATACGTATTGCATCACCCGGAAGAGAAAAGCCGTTCAGGTTTTCTGGCATCGGCAGCACTGAAGGTGTTGCAGG
AGAGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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