Detailed information of TA system TA167978

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 56001..56270
• Replicon: plasmid pIncFII
• Accession: NZ_CP058942
• Organism: Klebsiella pneumoniae strain BA39649

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: HBJ39_RS27995
• Protein ID: WP_001372321.1
• Coordinates: 56145..56270 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	56001..56066 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HBJ39_RS27970	51711..52238	+	528	WP_000290834.1	single-stranded DNA-binding protein	-
HBJ39_RS27975	52296..52529	+	234	WP_000006003.1	DUF905 family protein	-
HBJ39_RS27980	52590..54613	+	2024	Protein_65	ParB/RepB/Spo0J family partition protein	-
HBJ39_RS27985	54682..55116	+	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
HBJ39_RS27990	55113..55832	+	720	WP_001276217.1	plasmid SOS inhibition protein A	-
-	55844..56068	+	225	NuclAT_0	-	-
-	55844..56068	+	225	NuclAT_0	-	-
-	55844..56068	+	225	NuclAT_0	-	-
-	55844..56068	+	225	NuclAT_0	-	-
-	56001..56066	-	66	-	-	Antitoxin
HBJ39_RS29600	56054..56203	+	150	Protein_68	plasmid maintenance protein Mok	-
HBJ39_RS27995	56145..56270	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
HBJ39_RS28000	56589..56885	-	297	Protein_70	hypothetical protein	-
HBJ39_RS28005	57185..57481	+	297	WP_001272251.1	hypothetical protein	-
HBJ39_RS28010	57592..58413	+	822	WP_001234445.1	DUF932 domain-containing protein	-
HBJ39_RS28015	58710..59300	-	591	WP_000252683.1	transglycosylase SLT domain-containing protein	-
HBJ39_RS28020	59635..60018	+	384	WP_001354030.1	conjugal transfer relaxosome DNA-binding protein TraM	-
HBJ39_RS28025	60212..60883	+	672	WP_000283561.1	conjugal transfer transcriptional regulator TraJ	-
HBJ39_RS28030	61020..61247	+	228	WP_000089263.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T167978 WP_001372321.1 NZ_CP058942:56145-56270 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T167978 NZ_CP075550:c56312-55896 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT167978 NZ_CP058942:c56066-56001 [Klebsiella pneumoniae]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Antitoxin