Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2647601..2648189 Replicon chromosome
Accession NZ_CP058907
Organism Rhodopseudomonas palustris strain CGMCC 1.2180

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag HZF03_RS12095 Protein ID WP_119018298.1
Coordinates 2647601..2647888 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HZF03_RS12100 Protein ID WP_119018299.1
Coordinates 2647902..2648189 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZF03_RS12070 2643221..2644726 + 1506 WP_119018294.1 caspase family protein -
HZF03_RS12075 2644781..2645617 - 837 WP_119018295.1 helix-turn-helix transcriptional regulator -
HZF03_RS12080 2645716..2646621 + 906 WP_119018296.1 SDR family oxidoreductase -
HZF03_RS12085 2646655..2646843 - 189 WP_042441071.1 hypothetical protein -
HZF03_RS12090 2646989..2647459 - 471 WP_119018297.1 hypothetical protein -
HZF03_RS12095 2647601..2647888 + 288 WP_119018298.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZF03_RS12100 2647902..2648189 + 288 WP_119018299.1 HigA family addiction module antidote protein Antitoxin
HZF03_RS12105 2648202..2650253 - 2052 WP_119018300.1 DNA topoisomerase IV subunit B -
HZF03_RS12110 2650711..2651241 + 531 WP_119018301.1 DedA family protein -
HZF03_RS12115 2651327..2652316 + 990 WP_179906307.1 MBL fold metallo-hydrolase -
HZF03_RS12120 2652461..2653006 - 546 WP_119018303.1 DUF2087 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-59)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11074.71 Da        Isoelectric Point: 10.2688

>T167955 WP_119018298.1 NZ_CP058907:2647601-2647888 [Rhodopseudomonas palustris]
MIRSWRNAATRKLWDGSRFDQFRGLDVEAAIDLLLALNAAKSLQDLNPLQSVGLHKLKGVRRNQWAMTVNDRWRICFEFR
KGDAFEVEIVDYHKG

Download         Length: 288 bp

>T167955 NZ_CP075487:c2956183-2955806 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAGCTTATTGCAATTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCAGGCATGCC
AGATTCGGGAAGAGCTGAGGCTATTATCGGGAGAGTCCAGGCCAGAGTTGCATATGAAGAGATTACCGACCTTTTCGAAG
TCTCCGCAACTTACCTGGTGGCTACTGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
TTGTTATTTCTGCGCCGTAACGGTGTGCAGGTATATGATTCACCAGAACTGGCAGAGCTTACTGTGGGGGCTGCGACCGG
AGAGGTATCCGTATCTACTGTCGTTGCCACGTTACGTAGATTGTATGGTACGGCGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10512.01 Da        Isoelectric Point: 10.6604

>AT167955 WP_119018299.1 NZ_CP058907:2647902-2648189 [Rhodopseudomonas palustris]
MTPVSHPGRLLKRELAARKLSANRLALDIGVPSGRITDILNGRRSITADTAVRLGRYFGNAPQFWLDLQSQYDIAVIERD
KGAEIDRQVRPADAA

Download         Length: 288 bp

>AT167955 NZ_CP075487:c2956404-2956183 [Escherichia coli]
ATGCAATCTATTAACTTCCGTACCGCACGCAGCAATCTTACCGAAGTGCTCAACAATGTTGAAGCCGGAGAAGAGGTTGA
AATCACCCGTAGAGGTCGTGAGCCAGCTGTAATTGTCAGCAAGGCCACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTCGCATCCCTGTTTGACACTCTGGACACCACCAATAAGAAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References