Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 87912..88447 Replicon plasmid plas4
Accession NZ_CP058895
Organism Enterococcus faecium strain ef332

Toxin (Protein)


Gene name yoeB Uniprot ID R2PQC0
Locus tag HZU50_RS14720 Protein ID WP_002314366.1
Coordinates 87912..88184 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q3Y220
Locus tag HZU50_RS14725 Protein ID WP_002297422.1
Coordinates 88184..88447 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZU50_RS14685 (HZU50_14685) 83550..84089 - 540 WP_010728942.1 hypothetical protein -
HZU50_RS14690 (HZU50_14690) 84229..84909 - 681 Protein_86 IS6-like element ISS1N family transposase -
HZU50_RS14695 (HZU50_14695) 85118..85279 - 162 WP_002349958.1 hypothetical protein -
HZU50_RS14700 (HZU50_14700) 85539..86087 - 549 WP_002292681.1 hypothetical protein -
HZU50_RS14705 (HZU50_14705) 86088..86945 - 858 WP_002292680.1 ParA family protein -
HZU50_RS14710 (HZU50_14710) 87229..87516 - 288 WP_002300557.1 type II toxin-antitoxin system RelE/ParE family toxin -
HZU50_RS14715 (HZU50_14715) 87506..87835 - 330 WP_002292678.1 AbrB family transcriptional regulator -
HZU50_RS14720 (HZU50_14720) 87912..88184 - 273 WP_002314366.1 Txe/YoeB family addiction module toxin Toxin
HZU50_RS14725 (HZU50_14725) 88184..88447 - 264 WP_002297422.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HZU50_RS14730 (HZU50_14730) 88681..89589 + 909 Protein_94 IS982-like element ISEfm1 family transposase -
HZU50_RS14735 (HZU50_14735) 89592..90767 - 1176 WP_002336205.1 MFS transporter -
HZU50_RS14740 (HZU50_14740) 90770..93019 - 2250 WP_002314387.1 alpha-galactosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid aac(6')-aph(2'') - 1..203651 203651
- inside IScluster/Tn - - 80029..100939 20910


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10780.24 Da        Isoelectric Point: 9.9724

>T167952 WP_002314366.1 NZ_CP058895:c88184-87912 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

>T167952 NZ_CP075487:2595779-2595886 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9959.22 Da        Isoelectric Point: 4.5370

>AT167952 WP_002297422.1 NZ_CP058895:c88447-88184 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp

>AT167952 NZ_CP075487:c2595732-2595666 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829F704

Antitoxin

Source ID Structure
AlphaFold DB A0A829F006

References