167930

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1767038..1767540 Replicon chromosome
Accession NZ_CP058886
Organism Shigella flexneri strain STLEFF_33

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag HZT25_RS08480 Protein ID WP_000767829.1
Coordinates 1767286..1767540 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HZT25_RS08475 Protein ID WP_001259255.1
Coordinates 1767038..1767289 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT25_RS08450 (1762215) 1762215..1763282 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
HZT25_RS08455 (1763282) 1763282..1764352 - 1071 WP_000108945.1 histidinol-phosphate transaminase -
HZT25_RS08460 (1764349) 1764349..1765653 - 1305 WP_001446927.1 histidinol dehydrogenase -
HZT25_RS08465 (1765659) 1765659..1766558 - 900 WP_032329340.1 ATP phosphoribosyltransferase -
HZT25_RS08470 (1766704) 1766704..1766754 - 51 WP_001364200.1 his operon leader peptide -
HZT25_RS08475 (1767038) 1767038..1767289 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HZT25_RS08480 (1767286) 1767286..1767540 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HZT25_RS08485 (1767623) 1767623..1768447 + 825 WP_000754737.1 SDR family oxidoreductase -
HZT25_RS08490 (1768493) 1768493..1769422 + 930 Protein_1666 LysR substrate-binding domain-containing protein -
HZT25_RS08495 (1769637) 1769637..1769699 + 63 WP_010723108.1 membrane protein YoeI -
HZT25_RS08500 (1769689) 1769689..1771047 + 1359 WP_096132054.1 putrescine/proton symporter PlaP -
HZT25_RS08505 (1771226) 1771226..1772284 + 1059 WP_000492324.1 thiosulfate utilization transporter TsuA/YeeE -
HZT25_RS08510 (1772298) 1772298..1772525 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T167930 WP_000767829.1 NZ_CP058886:1767286-1767540 [Shigella flexneri]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T167930 NZ_CP075484:2689183-2689290 [Escherichia coli]
ATGACGCTCGCGCAGTTTACCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT167930 WP_001259255.1 NZ_CP058886:1767038-1767289 [Shigella flexneri]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT167930 NZ_CP075484:c2689136-2689070 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References