Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 789708..790401 Replicon chromosome
Accession NZ_CP058879
Organism Escherichia coli strain STLEFF_29

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HZT24_RS03835 Protein ID WP_000415584.1
Coordinates 789708..790004 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HZT24_RS03840 Protein ID WP_000650107.1
Coordinates 790006..790401 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT24_RS03800 (784796) 784796..785110 - 315 WP_000958598.1 putative quinol monooxygenase -
HZT24_RS03805 (785141) 785141..785722 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HZT24_RS03810 (786041) 786041..786373 + 333 WP_023149630.1 DUF2645 family protein -
HZT24_RS03815 (786419) 786419..787768 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
HZT24_RS03820 (787765) 787765..788424 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
HZT24_RS03825 (788576) 788576..788968 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HZT24_RS03830 (789021) 789021..789503 + 483 WP_000183505.1 GyrI-like domain-containing protein -
HZT24_RS03835 (789708) 789708..790004 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HZT24_RS03840 (790006) 790006..790401 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HZT24_RS03845 (790534) 790534..792141 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HZT24_RS03850 (792279) 792279..794537 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T167891 WP_000415584.1 NZ_CP058879:789708-790004 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T167891 NZ_CP075477:c4089188-4088838 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT167891 WP_000650107.1 NZ_CP058879:790006-790401 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT167891 NZ_CP075477:c4089433-4089182 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References