Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 73050..73314 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP058876 | ||
| Organism | Escherichia coli strain STLEFF_47 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | U9Y6M3 |
| Locus tag | HZT32_RS25310 | Protein ID | WP_001331364.1 |
| Coordinates | 73162..73314 (+) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 73050..73107 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HZT32_RS25295 (68289) | 68289..70580 | - | 2292 | WP_001289272.1 | F-type conjugative transfer protein TrbC | - |
| HZT32_RS25300 (70573) | 70573..71643 | - | 1071 | WP_001535705.1 | IncI1-type conjugal transfer protein TrbB | - |
| HZT32_RS25305 (71662) | 71662..72870 | - | 1209 | WP_001535704.1 | IncI1-type conjugal transfer protein TrbA | - |
| - (73050) | 73050..73107 | - | 58 | NuclAT_0 | - | Antitoxin |
| - (73050) | 73050..73107 | - | 58 | NuclAT_0 | - | Antitoxin |
| - (73050) | 73050..73107 | - | 58 | NuclAT_0 | - | Antitoxin |
| - (73050) | 73050..73107 | - | 58 | NuclAT_0 | - | Antitoxin |
| HZT32_RS25310 (73162) | 73162..73314 | + | 153 | WP_001331364.1 | Hok/Gef family protein | Toxin |
| HZT32_RS25315 (73386) | 73386..73637 | - | 252 | WP_001535703.1 | hypothetical protein | - |
| HZT32_RS26160 (74138) | 74138..74233 | + | 96 | WP_000609148.1 | DinQ-like type I toxin DqlB | - |
| HZT32_RS25325 (74298) | 74298..74474 | - | 177 | WP_001054904.1 | hypothetical protein | - |
| HZT32_RS25330 (74683) | 74683..74892 | - | 210 | WP_001140545.1 | hemolysin expression modulator Hha | - |
| HZT32_RS25335 (74990) | 74990..75604 | - | 615 | WP_000578649.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
| HZT32_RS25340 (75680) | 75680..77848 | - | 2169 | WP_000698360.1 | IncI1-type conjugal transfer membrane protein TraY | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | tet(A) / qnrS1 / ARR-3 / cmlA1 / blaOXA-10 / ant(3'')-Ia / dfrA14 / sul2 / aph(3'')-Ib / aph(6)-Id / floR | - | 1..121650 | 121650 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5775.13 Da Isoelectric Point: 8.7948
>T167879 WP_001331364.1 NZ_CP058876:73162-73314 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T167879 NZ_CP075477:1859123-1859374 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA
Antitoxin
Download Length: 58 bp
>AT167879 NZ_CP058876:c73107-73050 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
