Detailed information of TA system TA167871

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 97905..98174
• Replicon: plasmid unnamed1
• Accession: NZ_CP058875
• Organism: Escherichia coli strain STLEFF_47

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: HZT32_RS24570
• Protein ID: WP_001372321.1
• Coordinates: 98049..98174 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	97905..97970 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT32_RS24530	92971..93225	+	255	WP_072163210.1	hypothetical protein	-
HZT32_RS24535	93698..94225	+	528	WP_000290793.1	single-stranded DNA-binding protein	-
HZT32_RS24540	94281..94514	+	234	WP_000006004.1	DUF905 domain-containing protein	-
HZT32_RS24545	94573..96531	+	1959	WP_001145469.1	ParB/RepB/Spo0J family partition protein	-
HZT32_RS24550	96586..97020	+	435	WP_000845895.1	conjugation system SOS inhibitor PsiB	-
HZT32_RS24555	97017..97779	+	763	Protein_92	plasmid SOS inhibition protein A	-
HZT32_RS24560	97748..97936	-	189	WP_001299721.1	hypothetical protein	-
-	97748..97972	+	225	NuclAT_0	-	-
-	97748..97972	+	225	NuclAT_0	-	-
-	97748..97972	+	225	NuclAT_0	-	-
-	97748..97972	+	225	NuclAT_0	-	-
-	97905..97970	-	66	-	-	Antitoxin
HZT32_RS24565	97958..98107	+	150	Protein_94	plasmid maintenance protein Mok	-
HZT32_RS24570	98049..98174	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
HZT32_RS24575	98394..98624	+	231	WP_001426396.1	hypothetical protein	-
HZT32_RS24580	98622..98795	-	174	Protein_97	hypothetical protein	-
HZT32_RS24585	98865..99071	+	207	WP_000547939.1	hypothetical protein	-
HZT32_RS24590	99096..99383	+	288	WP_000107535.1	hypothetical protein	-
HZT32_RS24595	99504..100325	+	822	WP_224492277.1	DUF932 domain-containing protein	-
HZT32_RS24600	100622..101224	-	603	WP_000243709.1	transglycosylase SLT domain-containing protein	-
HZT32_RS24605	101545..101928	+	384	WP_001151524.1	conjugal transfer relaxosome DNA-binding protein TraM	-
HZT32_RS24610	102115..102804	+	690	WP_000283385.1	conjugal transfer transcriptional regulator TraJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	sitABCD	iroB / iroC / iroD / iroE / iroN / iucA / iucB / iucC / iucD / iutA / vat	1..152887	152887

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T167871 WP_001372321.1 NZ_CP058875:98049-98174 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T167871 NZ_CP075475:40935-41456 [Escherichia coli]
GTGAGCAATACGACGATCGGGATTTTCTCTGGAGAGAAAGATTATGATCTAAACGGTTTTGATTGCGGCGAAGAGTCGCT
AAACGCATTTTTGACCAACCACTTAAAAAGACAGCATGAAGGAAAAATTCTTCGCGCTTATGTGCTTTGCACTAAAGAAG
AAATACCAAAGGTATTAGGTTATTACACTTTGTCAGGCAGCTGCTTTGAGAAAGAAAACTTACCTTCAAAGAGTCAGCAA
AAGAAAGTGCCTTATCGGCATGTCCCAAGTATCACTTTAGGCAGACTGGCTTTGGACAAATCTCTTCAAGGTCAGGGGCT
TGGCTCAATGCTTGTAACTCACGCAATGCGTGTTGTGTACAATGCATCTCTTGCGGTAGGCATTCATGGGCTTTTCGTTG
AGGCGTTGAACGATAAAGCCAGGGCGTTTTATAAAAGTTTGGGCTTTATCCAGCTGGTTGGTAACAACGATCGTTCTTTG
TTCTATCCAACAAAATCTATCGAAAAATTGTTCGAAGAATAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT167871 NZ_CP058875:c97970-97905 [Escherichia coli]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Antitoxin