Detailed information of TA system TA167845

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 274489..274711
• Replicon: chromosome
• Accession: NZ_CP058874
• Organism: Escherichia coli strain STLEFF_47

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: HZT32_RS01330
• Protein ID: WP_001295224.1
• Coordinates: 274604..274711 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	274489..274547 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT32_RS01310	270360..271343	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
HZT32_RS01315	271340..272344	+	1005	WP_240724426.1	dipeptide ABC transporter ATP-binding subunit DppF	-
HZT32_RS01320	272374..273645	-	1272	WP_001318103.1	aromatic amino acid transport family protein	-
HZT32_RS01325	274121..274228	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	274489..274547	-	59	-	-	Antitoxin
HZT32_RS01330	274604..274711	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
HZT32_RS01335	274798..276477	-	1680	WP_001562264.1	cellulose biosynthesis protein BcsG	-
HZT32_RS01340	276474..276665	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
HZT32_RS01345	276662..278233	-	1572	WP_001204944.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
HZT32_RS01350	278506..278694	+	189	WP_001063315.1	cellulose biosynthesis protein BcsR	-
HZT32_RS01355	278706..279458	+	753	Protein_269	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T167845 WP_001295224.1 NZ_CP058874:274604-274711 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T167845 NZ_CP075472:2991641-2992027 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGTACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT167845 NZ_CP058874:c274547-274489 [Escherichia coli]
TCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin