Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3798183..3798780 Replicon chromosome
Accession NZ_CP058859
Organism Klebsiella quasipneumoniae strain STLEFF_28

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HZT23_RS18560 Protein ID WP_108450630.1
Coordinates 3798463..3798780 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HZT23_RS18555 Protein ID WP_108450629.1
Coordinates 3798183..3798470 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT23_RS18525 (3794270) 3794270..3794518 + 249 WP_002893037.1 DUF1158 domain-containing protein -
HZT23_RS18530 (3794536) 3794536..3794877 - 342 WP_004202492.1 RamA family antibiotic efflux transcriptional regulator -
HZT23_RS18535 (3794908) 3794908..3796023 - 1116 WP_025999133.1 MBL fold metallo-hydrolase -
HZT23_RS18540 (3796203) 3796203..3796784 + 582 WP_240708741.1 TetR/AcrR family transcriptional regulator -
HZT23_RS18545 (3796784) 3796784..3797152 + 369 WP_004202487.1 MmcQ/YjbR family DNA-binding protein -
HZT23_RS18550 (3797272) 3797272..3797925 + 654 WP_108450628.1 oxygen-insensitive NAD(P)H nitroreductase -
HZT23_RS18555 (3798183) 3798183..3798470 - 288 WP_108450629.1 helix-turn-helix transcriptional regulator Antitoxin
HZT23_RS18560 (3798463) 3798463..3798780 - 318 WP_108450630.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZT23_RS18565 (3798965) 3798965..3800008 - 1044 WP_060656299.1 hypothetical protein -
HZT23_RS18570 (3800546) 3800546..3801412 - 867 WP_158239951.1 helix-turn-helix transcriptional regulator -
HZT23_RS18575 (3801521) 3801521..3802948 + 1428 WP_023319904.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12197.57 Da        Isoelectric Point: 11.2767

>T167791 WP_108450630.1 NZ_CP058859:c3798780-3798463 [Klebsiella quasipneumoniae]
MFRMVVHVDVKKELQALPAIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQNKTLFLLRVF
VKKTQKIPLSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T167791 NZ_CP075465:170868-170975 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10840.56 Da        Isoelectric Point: 10.4518

>AT167791 WP_108450629.1 NZ_CP058859:c3798470-3798183 [Klebsiella quasipneumoniae]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERKHRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRTSLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT167791 NZ_CP075465:c170820-170754 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References