167709

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 723679..724372 Replicon chromosome
Accession NZ_CP058849
Organism Shigella flexneri strain STLEFF_36

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HZT28_RS03520 Protein ID WP_000415584.1
Coordinates 724076..724372 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HZT28_RS03515 Protein ID WP_000650107.1
Coordinates 723679..724074 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT28_RS03505 (719543) 719543..721801 - 2259 WP_049253102.1 DNA topoisomerase IV subunit A -
HZT28_RS03510 (721939) 721939..723546 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HZT28_RS03515 (723679) 723679..724074 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HZT28_RS03520 (724076) 724076..724372 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HZT28_RS03525 (724577) 724577..725059 - 483 WP_000183505.1 GyrI-like domain-containing protein -
HZT28_RS03530 (725112) 725112..725504 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HZT28_RS03535 (725656) 725656..726315 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
HZT28_RS03540 (726312) 726312..727661 + 1350 WP_001618857.1 quorum sensing histidine kinase QseC -
HZT28_RS03545 (727707) 727707..728039 - 333 WP_000917684.1 DUF2645 family protein -
HZT28_RS03550 (728358) 728358..728939 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HZT28_RS03555 (728970) 728970..729284 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T167709 WP_000415584.1 NZ_CP058849:c724372-724076 [Shigella flexneri]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T167709 NZ_CP075358:c9725-9348 [Pseudochrobactrum algeriensis]
ATGAATGACGACGAGCGCCCGCTAGAATGGATCGGTAGCAGCTACAAAGACCTGATGCAGCTTCCTGCCGATGTGCGGAA
GTTTTTCGGTTTTGCGCTTAGTTTCGCGCAGCAGGGCGAGCAGCACGCCGCCGCAAAAGTCCTCAAAGGATTTGGCGGCG
CTGGTGTCCTCGAACTGGTCGAGAACGACGCTGGCGGGACATATCGGGCCGTGTACACGGTCAAATTCGAGGAAGCTGTT
TTCGTGCTGCATTGCTTTCAGAAGAAGAGCAAGAGCGGCATCGCCACACCGAAAGCGGACATGGACGTTATCCGCGCCCG
GTTGAAGGTGGCGGAGATAGTGGCGAAGGAGATGAGACATGAGAACCCGCATCGTTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT167709 WP_000650107.1 NZ_CP058849:c724074-723679 [Shigella flexneri]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT167709 NZ_CP075358:c9367-9032 [Pseudochrobactrum algeriensis]
ATGAGAACCCGCATCGTTAATGGGGTCGAGGTCACGACGAGTTCCGGCAATGTCTTTGCCGATCTCGGCCTACCCGATGC
CGAAAAGCTGAAAATGAAATCCGGTCTGATGATCGAGATCACTAAGGCCGTGCGTCGGCTCGACCTTACACAAGAGGAAG
CCGGGCGGCGCATGGGACTTCCGCAGCCGAAAGTGTCGGCGCTCCTACGGGGCGACTTCACAAACCTCTCGGAACGGAAG
CTGATGGAATGTCTGAACCGGCTTGGTTACGACATCGAAATTACAGTGAAGCCGGCCGCCGATGCTGTCGGGCATATGAC
GCTCGCGGTAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References