Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3694928..3695621 Replicon chromosome
Accession NZ_CP058846
Organism Shigella flexneri strain STLEFF_35

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HZT27_RS18140 Protein ID WP_000415584.1
Coordinates 3695325..3695621 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HZT27_RS18135 Protein ID WP_000650107.1
Coordinates 3694928..3695323 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT27_RS18125 (3690792) 3690792..3693050 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
HZT27_RS18130 (3693188) 3693188..3694795 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HZT27_RS18135 (3694928) 3694928..3695323 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HZT27_RS18140 (3695325) 3695325..3695621 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HZT27_RS18145 (3695826) 3695826..3696308 - 483 WP_000183505.1 GyrI-like domain-containing protein -
HZT27_RS18150 (3696361) 3696361..3696753 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HZT27_RS18155 (3696905) 3696905..3697564 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
HZT27_RS18160 (3697561) 3697561..3698910 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
HZT27_RS18165 (3698956) 3698956..3699288 - 333 WP_000917684.1 DUF2645 family protein -
HZT27_RS18170 (3699607) 3699607..3700188 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HZT27_RS18175 (3700219) 3700219..3700533 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T167701 WP_000415584.1 NZ_CP058846:c3695621-3695325 [Shigella flexneri]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T167701 NZ_CP075345:1940379-1940482 [Enterobacter kobei]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT167701 WP_000650107.1 NZ_CP058846:c3695323-3694928 [Shigella flexneri]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT167701 NZ_CP075345:c1940489-1940344 [Enterobacter kobei]
AATAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References