Detailed information of TA system TA167684

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1912311..1912682
• Replicon: chromosome
• Accession: NZ_CP058846
• Organism: Shigella flexneri strain STLEFF_35

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: F4VC37
• Locus tag: HZT27_RS09220
• Protein ID: WP_001317028.1
• Coordinates: 1912488..1912682 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1912311..1912489 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT27_RS24045 (1908063)	1908063..1908236	+	174	WP_001296046.1	protein YnaL	-
HZT27_RS09195 (1908266)	1908266..1909639	+	1374	WP_134234849.1	ATP-dependent RNA helicase DbpA	-
HZT27_RS09200 (1909768)	1909768..1910703	-	936	WP_001157377.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
HZT27_RS09205 (1910755)	1910755..1911990	-	1236	WP_000040842.1	site-specific integrase	-
HZT27_RS09210 (1911992)	1911992..1912207	-	216	WP_000079604.1	excisionase XisR	-
- (1912311)	1912311..1912489	+	179	NuclAT_0	-	Antitoxin
- (1912311)	1912311..1912489	+	179	NuclAT_0	-	Antitoxin
- (1912311)	1912311..1912489	+	179	NuclAT_0	-	Antitoxin
- (1912311)	1912311..1912489	+	179	NuclAT_0	-	Antitoxin
HZT27_RS09215 (1912307)	1912307..1912495	-	189	WP_001302840.1	DUF1187 family protein	-
HZT27_RS09220 (1912488)	1912488..1912682	-	195	WP_001317028.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
HZT27_RS09225 (1912739)	1912739..1913548	-	810	WP_134234848.1	recombination protein RecT	-
HZT27_RS09230 (1913541)	1913541..1916141	-	2601	WP_240767107.1	exodeoxyribonuclease VIII	-
HZT27_RS09235 (1916243)	1916243..1916518	-	276	WP_001344816.1	hypothetical protein	-
HZT27_RS09240 (1916593)	1916593..1916763	-	171	WP_001352098.1	YdaE family protein	-
HZT27_RS09245 (1916763)	1916763..1916984	-	222	WP_000560223.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1910755..1930947	20192

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7018.89 Da
• Isoelectric Point: 8.9538

>T167684 WP_001317028.1 NZ_CP058846:c1912682-1912488 [Shigella flexneri]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T167684 NZ_CP075334:c1911-1567 [Lactiplantibacillus plantarum]
ATGGTAAGCCAAGGTGATATATTTTATGTTAACTTTAATCCAAGCCGTGGTCATGAACAGATGAATAAGCGACCAGCCAT
TGCGCTAAGCAATGATCTAGTCTGTCAGACAAGTAACATGACGATTGTGGCTCCAATTAGCAGTACCAAGCGTAATTTTC
CAATGTATCATCGACTAACTAGTAGTCAAACAGTATATGGAAAAGTATTATTAGATCAAACCATAGCCTTAGATTTACGG
GCAAGACATGTCACTGATGAAACTATTGTCGATCATGTATCGCGTGAAGAACTAGAAGAAATAATCACTTTGTACAAATT
ATTGTTTAGTATTGATGACAAATAG

Antitoxin

Nucleotide

• Length: 179 bp

>AT167684 NZ_CP058846:1912311-1912489 [Shigella flexneri]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A7L6LHV7

Antitoxin