Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4077206..4077747 Replicon chromosome
Accession NZ_CP058839
Organism Shigella flexneri strain STLEFF_34

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag HZT26_RS19840 Protein ID WP_000615983.1
Coordinates 4077206..4077484 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag HZT26_RS19845 Protein ID WP_000729703.1
Coordinates 4077487..4077747 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT26_RS19825 (4074788) 4074788..4075366 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
HZT26_RS19830 (4075572) 4075572..4076339 + 768 WP_000333380.1 class II glutamine amidotransferase -
HZT26_RS19835 (4076310) 4076310..4077050 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
HZT26_RS19840 (4077206) 4077206..4077484 - 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
HZT26_RS19845 (4077487) 4077487..4077747 - 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
HZT26_RS19850 (4077957) 4077957..4078706 + 750 WP_000056849.1 C40 family peptidase -
HZT26_RS19855 (4078882) 4078882..4079379 + 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
HZT26_RS19860 (4079603) 4079603..4081315 - 1713 Protein_3884 flagellar biosynthesis protein FlhA -
HZT26_RS19865 (4081287) 4081287..4082072 + 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - tssC / tssB / hcp2/tssD2 / gmhA/lpcA 4054154..4079379 25225


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T167671 WP_000615983.1 NZ_CP058839:c4077484-4077206 [Shigella flexneri]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T167671 NZ_CP075323:480444-480833 [Acinetobacter sp. BHS4]
TTGATAAAAGAATTAAATTTTGAGCTGAAATATAGCCGTGTCTCGGTAATATTTCAGCTTTTTGTTGGTTTGGGTTTAGC
AATCCTGCTTTATCAATTATTAACACCGATATGGTGGCTATGTGCTGTCATTCTTCTATTTATTGGTTTTATTTTCTTTC
TAAAGCAAGCCCAAATATCTCAAATTGAATATTTAGATCAAAAATTATGGTCGGTTACATATTTTTCGAAAAAAGAAATT
TACCGTGCGGAAATTACTAAAATAATTGATTATCAGTTATTTGTAGTTATTTATCTTGAAGAAACTCCTACGAACATAGC
TATTGTTTGGTTCGATCAGCTTCCTATTCAGCAGTGGAAAAGATTAAAAGTTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT167671 WP_000729703.1 NZ_CP058839:c4077747-4077487 [Shigella flexneri]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT167671 NZ_CP075323:480180-480437 [Acinetobacter sp. BHS4]
ATGTCTGACGAAATGACCTTGGAAGAACGTAAAGTAATTTATCGAGCACGCCGTGGCTTAAAAGAAATTGACGTCTATTT
TGACCCGTATGTAAAAAATTATTATTTAAAAGCTGATCCAGCAGAAAAAGCATTATTTGCAGAGCTAGTTGATCAAGAAG
ATCCAGATTTATTAGATTGGTTCATGGAAGTTTCTGAGCCTCCACGTACTGAGTTACGTGAATTTATTTATAAACTAAAA
CAGTATGTGCATGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References