Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2290532..2291225 Replicon chromosome
Accession NZ_CP058839
Organism Shigella flexneri strain STLEFF_34

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HZT26_RS11215 Protein ID WP_000415584.1
Coordinates 2290929..2291225 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HZT26_RS11210 Protein ID WP_000650107.1
Coordinates 2290532..2290927 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT26_RS11200 (2286396) 2286396..2288654 - 2259 WP_049253102.1 DNA topoisomerase IV subunit A -
HZT26_RS11205 (2288792) 2288792..2290399 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HZT26_RS11210 (2290532) 2290532..2290927 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HZT26_RS11215 (2290929) 2290929..2291225 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HZT26_RS11220 (2291430) 2291430..2291912 - 483 WP_000183505.1 GyrI-like domain-containing protein -
HZT26_RS11225 (2291965) 2291965..2292357 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HZT26_RS11230 (2292509) 2292509..2293168 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
HZT26_RS11235 (2293165) 2293165..2294514 + 1350 WP_001618857.1 quorum sensing histidine kinase QseC -
HZT26_RS11240 (2294560) 2294560..2294892 - 333 WP_000917684.1 DUF2645 family protein -
HZT26_RS11245 (2295211) 2295211..2295792 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HZT26_RS11250 (2295823) 2295823..2296137 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T167666 WP_000415584.1 NZ_CP058839:c2291225-2290929 [Shigella flexneri]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T167666 NZ_CP075318:c6193-5888 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGATGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT167666 WP_000650107.1 NZ_CP058839:c2290927-2290532 [Shigella flexneri]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT167666 NZ_CP075318:c6413-6195 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References