Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2291732..2292425 Replicon chromosome
Accession NZ_CP058833
Organism Shigella flexneri strain STLEFF_27

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HZT22_RS11205 Protein ID WP_000415584.1
Coordinates 2292129..2292425 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HZT22_RS11200 Protein ID WP_000650107.1
Coordinates 2291732..2292127 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT22_RS11190 (2287596) 2287596..2289854 - 2259 WP_049253102.1 DNA topoisomerase IV subunit A -
HZT22_RS11195 (2289992) 2289992..2291599 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HZT22_RS11200 (2291732) 2291732..2292127 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HZT22_RS11205 (2292129) 2292129..2292425 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HZT22_RS11210 (2292630) 2292630..2293112 - 483 WP_000183505.1 GyrI-like domain-containing protein -
HZT22_RS11215 (2293165) 2293165..2293557 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HZT22_RS11220 (2293709) 2293709..2294368 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
HZT22_RS11225 (2294365) 2294365..2295714 + 1350 WP_001618857.1 quorum sensing histidine kinase QseC -
HZT22_RS11230 (2295760) 2295760..2296092 - 333 WP_000917684.1 DUF2645 family protein -
HZT22_RS11235 (2296411) 2296411..2296992 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HZT22_RS11240 (2297023) 2297023..2297337 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T167639 WP_000415584.1 NZ_CP058833:c2292425-2292129 [Shigella flexneri]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T167639 NZ_CP075286:324752-325120 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT167639 WP_000650107.1 NZ_CP058833:c2292127-2291732 [Shigella flexneri]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT167639 NZ_CP075286:324534-324755 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References