Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 712734..713427 Replicon chromosome
Accession NZ_CP058831
Organism Shigella flexneri strain STLE4

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HZT21_RS03475 Protein ID WP_000415584.1
Coordinates 712734..713030 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HZT21_RS03480 Protein ID WP_000650107.1
Coordinates 713032..713427 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT21_RS03440 (707822) 707822..708136 - 315 WP_000958598.1 putative quinol monooxygenase -
HZT21_RS03445 (708167) 708167..708748 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HZT21_RS03450 (709067) 709067..709399 + 333 WP_000917684.1 DUF2645 family protein -
HZT21_RS03455 (709445) 709445..710794 - 1350 WP_001618857.1 quorum sensing histidine kinase QseC -
HZT21_RS03460 (710791) 710791..711450 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
HZT21_RS03465 (711602) 711602..711994 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HZT21_RS03470 (712047) 712047..712529 + 483 WP_000183505.1 GyrI-like domain-containing protein -
HZT21_RS03475 (712734) 712734..713030 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HZT21_RS03480 (713032) 713032..713427 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HZT21_RS03485 (713560) 713560..715167 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HZT21_RS03490 (715305) 715305..717563 + 2259 WP_049253102.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T167602 WP_000415584.1 NZ_CP058831:712734-713030 [Shigella flexneri]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T167602 NZ_CP075189:2177270-2177671 [Ferribacterium limneticum]
ATGCGTTTCATGCTTGATACCAACATTTGCATTTACGCGATCAAGAACCGGCCGGCTGAGGTGCTGCAGGCGTTGCGGGC
GCATGAGGCGGCCGGTATCGGTGTGTCAAGTATTACCGTGGCCGAGTTGTTTTTCGGTGTCGAAAAAAGTGGCTCGGGAA
AAAATCGTCTGGCCTTGCAACATTTTCTGGAACCGCTGGAGATCGCAGATTTCGATGTGGCTGCGGCGCAGGTATATGGC
GCGGTAAGGCAGCAACTGGAGCTTGCCGGAACACCGATTGGCCCGCTGGATACGCAAATTGCAGCGCATGCCCTGTCGCT
CGGGGTGACTCTGGTGAGCAATAACCTTCGGGAGTTTTCCCGGGTCAAGGCGTTGCAGGTTGAGAATTGGGTTGGCGTTT
GA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT167602 WP_000650107.1 NZ_CP058831:713032-713427 [Shigella flexneri]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT167602 NZ_CP075189:2177019-2177258 [Ferribacterium limneticum]
ATGCAAACTGCAAAATTATTCCAGAATGGCCGTAGCCAAGCTGTTCGGTTGCCAAAGGCATTTCGTTTTGAAGGGGTGAG
CGAGGTTCGCATCGAGCGCGATGGTGATCGGGTCGTACTCAGTCCGGCATCGCGGCCTTCCATTGAGGGGTTGATTGCGG
CGCTGGATGAGTTTGATCGCGAGAATCCGATGCCGGAGCGCGAGCAGGTTGCCGCGCCCGATCAGCGCGAATCCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References