Detailed information of TA system TA167602

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 712734..713427
• Replicon: chromosome
• Accession: NZ_CP058831
• Organism: Shigella flexneri strain STLE4

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: S1EZG2
• Locus tag: HZT21_RS03475
• Protein ID: WP_000415584.1
• Coordinates: 712734..713030 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: S1EBV2
• Locus tag: HZT21_RS03480
• Protein ID: WP_000650107.1
• Coordinates: 713032..713427 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT21_RS03440 (707822)	707822..708136	-	315	WP_000958598.1	putative quinol monooxygenase	-
HZT21_RS03445 (708167)	708167..708748	-	582	WP_000065430.1	NADPH:quinone oxidoreductase MdaB	-
HZT21_RS03450 (709067)	709067..709399	+	333	WP_000917684.1	DUF2645 family protein	-
HZT21_RS03455 (709445)	709445..710794	-	1350	WP_001618857.1	quorum sensing histidine kinase QseC	-
HZT21_RS03460 (710791)	710791..711450	-	660	WP_001221493.1	quorum sensing response regulator transcription factor QseB	-
HZT21_RS03465 (711602)	711602..711994	+	393	WP_000712658.1	OB fold stress tolerance protein YgiW	-
HZT21_RS03470 (712047)	712047..712529	+	483	WP_000183505.1	GyrI-like domain-containing protein	-
HZT21_RS03475 (712734)	712734..713030	+	297	WP_000415584.1	type II toxin-antitoxin system toxin MqsR	Toxin
HZT21_RS03480 (713032)	713032..713427	+	396	WP_000650107.1	type II toxin-antitoxin system antitoxin MqsA	Antitoxin
HZT21_RS03485 (713560)	713560..715167	+	1608	WP_001295629.1	ABC transporter substrate-binding protein	-
HZT21_RS03490 (715305)	715305..717563	+	2259	WP_049253102.1	DNA topoisomerase IV subunit A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Zinc finger, MqsA-type (3-47)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11231.96 Da
• Isoelectric Point: 8.9070

>T167602 WP_000415584.1 NZ_CP058831:712734-713030 [Shigella flexneri]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Nucleotide

• Length: 297 bp

>T167602 NZ_CP075189:2177270-2177671 [Ferribacterium limneticum]
ATGCGTTTCATGCTTGATACCAACATTTGCATTTACGCGATCAAGAACCGGCCGGCTGAGGTGCTGCAGGCGTTGCGGGC
GCATGAGGCGGCCGGTATCGGTGTGTCAAGTATTACCGTGGCCGAGTTGTTTTTCGGTGTCGAAAAAAGTGGCTCGGGAA
AAAATCGTCTGGCCTTGCAACATTTTCTGGAACCGCTGGAGATCGCAGATTTCGATGTGGCTGCGGCGCAGGTATATGGC
GCGGTAAGGCAGCAACTGGAGCTTGCCGGAACACCGATTGGCCCGCTGGATACGCAAATTGCAGCGCATGCCCTGTCGCT
CGGGGTGACTCTGGTGAGCAATAACCTTCGGGAGTTTTCCCGGGTCAAGGCGTTGCAGGTTGAGAATTGGGTTGGCGTTT
GA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14703.10 Da
• Isoelectric Point: 9.2136

>AT167602 WP_000650107.1 NZ_CP058831:713032-713427 [Shigella flexneri]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Nucleotide

• Length: 396 bp

>AT167602 NZ_CP075189:2177019-2177258 [Ferribacterium limneticum]
ATGCAAACTGCAAAATTATTCCAGAATGGCCGTAGCCAAGCTGTTCGGTTGCCAAAGGCATTTCGTTTTGAAGGGGTGAG
CGAGGTTCGCATCGAGCGCGATGGTGATCGGGTCGTACTCAGTCCGGCATCGCGGCCTTCCATTGAGGGGTTGATTGCGG
CGCTGGATGAGTTTGATCGCGAGAATCCGATGCCGGAGCGCGAGCAGGTTGCCGCGCCCGATCAGCGCGAATCCTGGTAA

Structures

Toxin

• PDB: 3HI2

Antitoxin

• AlphaFold DB: A0A7U9LU65