Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 755177..755870 Replicon chromosome
Accession NZ_CP058828
Organism Shigella flexneri strain STLE3

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HZT20_RS03665 Protein ID WP_000415584.1
Coordinates 755177..755473 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HZT20_RS03670 Protein ID WP_000650107.1
Coordinates 755475..755870 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT20_RS03630 (750265) 750265..750579 - 315 WP_000958598.1 putative quinol monooxygenase -
HZT20_RS03635 (750610) 750610..751191 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HZT20_RS03640 (751510) 751510..751842 + 333 WP_000917684.1 DUF2645 family protein -
HZT20_RS03645 (751888) 751888..753237 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
HZT20_RS03650 (753234) 753234..753893 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
HZT20_RS03655 (754045) 754045..754437 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HZT20_RS03660 (754490) 754490..754972 + 483 WP_000183505.1 GyrI-like domain-containing protein -
HZT20_RS03665 (755177) 755177..755473 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HZT20_RS03670 (755475) 755475..755870 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HZT20_RS03675 (756003) 756003..757610 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HZT20_RS03680 (757748) 757748..760006 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T167578 WP_000415584.1 NZ_CP058828:755177-755473 [Shigella flexneri]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T167578 NZ_CP075174:1964287-1964390 [Salmonella enterica subsp. houtenae serovar 45:g,z51:-]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT167578 WP_000650107.1 NZ_CP058828:755475-755870 [Shigella flexneri]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT167578 NZ_CP075174:c1964392-1964249 [Salmonella enterica subsp. houtenae serovar 45:g,z51:-]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References