Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1811831..1812333 Replicon chromosome
Accession NZ_CP058826
Organism Shigella flexneri strain STLE1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7I6H4L3
Locus tag HZT18_RS08590 Protein ID WP_000767831.1
Coordinates 1812079..1812333 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HZT18_RS08585 Protein ID WP_001259255.1
Coordinates 1811831..1812082 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT18_RS08560 (1807008) 1807008..1808075 - 1068 WP_000080091.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
HZT18_RS08565 (1808075) 1808075..1809145 - 1071 WP_000108945.1 histidinol-phosphate transaminase -
HZT18_RS08570 (1809142) 1809142..1810446 - 1305 WP_001565639.1 histidinol dehydrogenase -
HZT18_RS08575 (1810452) 1810452..1811351 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
HZT18_RS08580 (1811497) 1811497..1811547 - 51 WP_001364200.1 his operon leader peptide -
HZT18_RS08585 (1811831) 1811831..1812082 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HZT18_RS08590 (1812079) 1812079..1812333 + 255 WP_000767831.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HZT18_RS08595 (1812416) 1812416..1813240 + 825 WP_000754737.1 SDR family oxidoreductase -
HZT18_RS08600 (1813286) 1813286..1814215 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
HZT18_RS08605 (1814430) 1814430..1814492 + 63 WP_010723108.1 membrane protein YoeI -
HZT18_RS08610 (1814482) 1814482..1815840 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
HZT18_RS08615 (1816019) 1816019..1817077 + 1059 WP_000492321.1 thiosulfate utilization transporter TsuA/YeeE -
HZT18_RS08620 (1817091) 1817091..1817318 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10231.67 Da        Isoelectric Point: 8.8202

>T167558 WP_000767831.1 NZ_CP058826:1812079-1812333 [Shigella flexneri]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTYDSLLIAAC
RYHY

Download         Length: 255 bp

>T167558 NZ_CP075169:3635246-3635551 [Sodalis ligni]
ATGCAATTTACTGTTTATCAGTATAAGCGGGCAAGCCATTACAAAATGTTTGTCGATGTGCAAAGTGATATTGTCGATAC
GCCAGGGCGGCGAATGGTCATCCCGCTGATAGCATCGCATCACCTGTCTGAAAAAGTGAATAAAACCTTGTTCCCCCTGA
TCCGCATCGACGGCGAAAATTACCGTCTGATGACAACTGAATTATCAAGCGTTTCCGTTGAGGTCATTGGTGAAATTATC
GCCGATGTAAGCCATTGTGCCAATGAAATCAAAAATGCTATCAATCTCATGTTCTGGGGTGTTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT167558 WP_001259255.1 NZ_CP058826:1811831-1812082 [Shigella flexneri]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT167558 NZ_CP075169:3635025-3635243 [Sodalis ligni]
ATGAAACACAGAGTCAGCGTTACCGTGGACAAAGACAATTATCAGGTTCTGAATGCTGCCGGCGTCAATATTTCTGGTCT
GGTGAATGAAGTCATCGGCAGGGAAGCCCGTCGCATAAAGGCTGAAGAATGGAAGAAAGAGAACCACGAAGGGATGGAGG
AAGTCGCCAGATTTATCGCACAGAATGGCTCTTTCGCCGATGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I6H4L3

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References