Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 656404..657131 | Replicon | chromosome |
| Accession | NZ_CP058826 | ||
| Organism | Shigella flexneri strain STLE1 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U9ZMR4 |
| Locus tag | HZT18_RS03200 | Protein ID | WP_000550189.1 |
| Coordinates | 656404..656718 (+) | Length | 105 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | HZT18_RS03205 | Protein ID | WP_000560255.1 |
| Coordinates | 656715..657131 (+) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HZT18_RS03180 (652570) | 652570..653556 | - | 987 | WP_000617698.1 | Gfo/Idh/MocA family oxidoreductase | - |
| HZT18_RS03185 (653635) | 653635..654318 | - | 684 | WP_001183041.1 | vancomycin high temperature exclusion protein | - |
| HZT18_RS03190 (654395) | 654395..654898 | - | 504 | WP_001295542.1 | M48 family metallopeptidase | - |
| HZT18_RS03195 (654983) | 654983..656119 | + | 1137 | WP_000018690.1 | 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG | - |
| HZT18_RS03200 (656404) | 656404..656718 | + | 315 | WP_000550189.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| HZT18_RS03205 (656715) | 656715..657131 | + | 417 | WP_000560255.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| HZT18_RS03210 (657176) | 657176..659194 | - | 2019 | WP_047632951.1 | NADPH-dependent 2,4-dienoyl-CoA reductase | - |
| HZT18_RS03215 (659520) | 659520..661871 | - | 2352 | WP_000695495.1 | alpha-glucosidase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 12103.10 Da Isoelectric Point: 10.0409
>T167555 WP_000550189.1 NZ_CP058826:656404-656718 [Shigella flexneri]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK
Download Length: 315 bp
>T167555 NZ_CP075169:2495340-2495915 [Sodalis ligni]
ATGATGCATTCACCCTATCCCGTAGTACTTGATGCCTGTGTGCTTTATCCGGCAAGACTGCGCGACCTGCTGATGCATTT
AGGTTTGGCCGGTTTGTACCAGCCTAAGTGGTCTGCGGTAATTCATGATGAATGGCGGTGTAATCTGTTGTTACAGCGAA
GCGACATCAACCCAGAGGCACTGGCACGAACAACGGATCTAATGAATCTGGCGCTGCCTGATGCCAATGTTACTGGATTT
GAAACGATTATCGAGGGTATCTCATTACCTGACCCCGACGATAGGCACGTTCTGGCTGCGGCAATCCGTTCGAATGCTGA
TGTGATTGTGACTCTGAACTTGAAGGATTTTCCAAGTGGAGTCTTGGCAGGATTTGGTATTGAAGCACTTCACCTAGATG
ATTTTATTTCGGATCTCTTTGATCTAAATCACTCGGTTGCGCTGAATGCCGTCAGATTACAACGCAACGCATTAAAAAAC
CCGCCAATGACGACTGAAGAATTCTTGGAGATGCTACTCAAGCAGGGACTCCCCATGACGGTCAAGGCTCTTAGAAATTA
CCAGTTTATGATTTAG
ATGATGCATTCACCCTATCCCGTAGTACTTGATGCCTGTGTGCTTTATCCGGCAAGACTGCGCGACCTGCTGATGCATTT
AGGTTTGGCCGGTTTGTACCAGCCTAAGTGGTCTGCGGTAATTCATGATGAATGGCGGTGTAATCTGTTGTTACAGCGAA
GCGACATCAACCCAGAGGCACTGGCACGAACAACGGATCTAATGAATCTGGCGCTGCCTGATGCCAATGTTACTGGATTT
GAAACGATTATCGAGGGTATCTCATTACCTGACCCCGACGATAGGCACGTTCTGGCTGCGGCAATCCGTTCGAATGCTGA
TGTGATTGTGACTCTGAACTTGAAGGATTTTCCAAGTGGAGTCTTGGCAGGATTTGGTATTGAAGCACTTCACCTAGATG
ATTTTATTTCGGATCTCTTTGATCTAAATCACTCGGTTGCGCTGAATGCCGTCAGATTACAACGCAACGCATTAAAAAAC
CCGCCAATGACGACTGAAGAATTCTTGGAGATGCTACTCAAGCAGGGACTCCCCATGACGGTCAAGGCTCTTAGAAATTA
CCAGTTTATGATTTAG
Antitoxin
Download Length: 139 a.a. Molecular weight: 14951.41 Da Isoelectric Point: 4.5577
>AT167555 WP_000560255.1 NZ_CP058826:656715-657131 [Shigella flexneri]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNAPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNAPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
Download Length: 417 bp
>AT167555 NZ_CP075169:2494791-2495336 [Sodalis ligni]
ATGGGCAGCTTCTTAAAGCTGCCATTGTTACCCCAGGTGGGTCAGATTTACATTGGTAGGTGGGTCATAATTACATCGGT
AGCGACAAATACCACGCTGACCGGACTGGCTCTTCCGGCAAAACATGAAATAGAAACGGCTATACGTGGCCAGCGTGACT
TGGCCGCTTTCCTCTCAACAAAGCTTGAGACGCAGCAGATTCTGATTAAAGATGCGGATGACGTCTCACACCAGATCGAA
CTACCTACCGCGGCCTTAACGTTGCTGATGAATGTGTTGGGTGAGCTGGCTGAAGGTAATGCCGTACAGGTTGTGCCGGT
GCATGCCGAACTGACGACGCAGGAAGCTGCAAATATCTTGAATGTTTCTCGGCCACACATGGTGAAACTACTCGAAGATG
GCCATCTACCGCATCACAAAACCGGCCGACACCGCCGAGTGTTGTTTGCAGACTTGATGGCCTACAAAAATGAGCGCGAT
GCTACCAGCCAAGAGGCTATGCAGAAGCTTGCGGCACAGGCCCAGGAACTCGGGTTAGGTTATTGA
ATGGGCAGCTTCTTAAAGCTGCCATTGTTACCCCAGGTGGGTCAGATTTACATTGGTAGGTGGGTCATAATTACATCGGT
AGCGACAAATACCACGCTGACCGGACTGGCTCTTCCGGCAAAACATGAAATAGAAACGGCTATACGTGGCCAGCGTGACT
TGGCCGCTTTCCTCTCAACAAAGCTTGAGACGCAGCAGATTCTGATTAAAGATGCGGATGACGTCTCACACCAGATCGAA
CTACCTACCGCGGCCTTAACGTTGCTGATGAATGTGTTGGGTGAGCTGGCTGAAGGTAATGCCGTACAGGTTGTGCCGGT
GCATGCCGAACTGACGACGCAGGAAGCTGCAAATATCTTGAATGTTTCTCGGCCACACATGGTGAAACTACTCGAAGATG
GCCATCTACCGCATCACAAAACCGGCCGACACCGCCGAGTGTTGTTTGCAGACTTGATGGCCTACAAAAATGAGCGCGAT
GCTACCAGCCAAGAGGCTATGCAGAAGCTTGCGGCACAGGCCCAGGAACTCGGGTTAGGTTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|