Detailed information of TA system TA167523

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 63885..64306
• Replicon: plasmid unnamed1
• Accession: NZ_CP058791
• Organism: Shigella flexneri strain STLIN_6

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: HZT08_RS23750
• Protein ID: WP_096937776.1
• Coordinates: 63885..64010 (-)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	64108..64306 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT08_RS23720 (60026)	60026..60664	-	639	WP_000777698.1	type-F conjugative transfer system pilin assembly protein TrbC	-
HZT08_RS23725 (60673)	60673..61665	-	993	WP_000830183.1	conjugal transfer pilus assembly protein TraU	-
HZT08_RS23730 (61662)	61662..62294	-	633	WP_001203720.1	type-F conjugative transfer system protein TraW	-
HZT08_RS23735 (62291)	62291..62677	-	387	WP_000099690.1	type-F conjugative transfer system protein TrbI	-
HZT08_RS23740 (62674)	62674..62991	-	318	Protein_73	hypothetical protein	-
HZT08_RS23745 (63307)	63307..63584	+	278	Protein_74	hypothetical protein	-
HZT08_RS23750 (63885)	63885..64010	-	126	WP_096937776.1	type I toxin-antitoxin system Hok family toxin	Toxin
HZT08_RS23755 (63952)	63952..64101	-	150	Protein_76	DUF5431 family protein	-
- (64108)	64108..64306	-	199	NuclAT_0	-	Antitoxin
- (64108)	64108..64306	-	199	NuclAT_0	-	Antitoxin
- (64108)	64108..64306	-	199	NuclAT_0	-	Antitoxin
- (64108)	64108..64306	-	199	NuclAT_0	-	Antitoxin
HZT08_RS23760 (64275)	64275..65037	-	763	Protein_77	plasmid SOS inhibition protein A	-
HZT08_RS23765 (65034)	65034..65468	-	435	WP_000845928.1	conjugation system SOS inhibitor PsiB	-
HZT08_RS23770 (65523)	65523..67481	-	1959	WP_000117171.1	ParB/RepB/Spo0J family partition protein	-
HZT08_RS23775 (67547)	67547..67780	-	234	WP_000005990.1	DUF905 family protein	-
HZT08_RS23780 (67837)	67837..68370	-	534	WP_240766720.1	single-stranded DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	estIa / paa / hlyD / hlyB / hlyA / hlyC	1..137079	137079

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4806.72 Da
• Isoelectric Point: 8.4890

>T167523 WP_096937776.1 NZ_CP058791:c64010-63885 [Shigella flexneri]
VLIVCLTLLIFTYLTRKSLCEIRYRDGYREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T167523 NZ_CP075140:2078230-2078333 [Salmonella enterica]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 199 bp

>AT167523 NZ_CP058791:c64306-64108 [Shigella flexneri]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGGATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAGGA
CAAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC

Structures

Antitoxin