Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 34876..35130 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP058791 | ||
| Organism | Shigella flexneri strain STLIN_6 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | A0A1D7QA06 |
| Locus tag | HZT08_RS23590 | Protein ID | WP_001367749.1 |
| Coordinates | 34876..35025 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 35069..35130 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HZT08_RS23560 (31002) | 31002..31322 | - | 321 | Protein_38 | Tn3 family transposase | - |
| HZT08_RS23565 (31536) | 31536..32294 | + | 759 | WP_001257942.1 | substrate-binding domain-containing protein | - |
| HZT08_RS23570 (33174) | 33174..34031 | - | 858 | WP_000130970.1 | incFII family plasmid replication initiator RepA | - |
| HZT08_RS24445 (34024) | 34024..34098 | - | 75 | WP_001375168.1 | RepA leader peptide Tap | - |
| HZT08_RS23585 (34344) | 34344..34592 | - | 249 | WP_000083838.1 | replication regulatory protein RepA | - |
| HZT08_RS23590 (34876) | 34876..35025 | - | 150 | WP_001367749.1 | Hok/Gef family protein | Toxin |
| - (35069) | 35069..35130 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (35069) | 35069..35130 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (35069) | 35069..35130 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (35069) | 35069..35130 | + | 62 | NuclAT_1 | - | Antitoxin |
| HZT08_RS23595 (35389) | 35389..35631 | - | 243 | WP_000504693.1 | hypothetical protein | - |
| HZT08_RS23600 (35710) | 35710..36407 | + | 698 | WP_103215986.1 | IS1-like element IS1A family transposase | - |
| HZT08_RS23605 (37186) | 37186..37389 | - | 204 | WP_001375146.1 | hypothetical protein | - |
| HZT08_RS23610 (37544) | 37544..38101 | - | 558 | WP_000139319.1 | fertility inhibition protein FinO | - |
| HZT08_RS23615 (38204) | 38204..39064 | - | 861 | WP_000868986.1 | alpha/beta hydrolase | - |
| HZT08_RS23620 (39123) | 39123..39869 | - | 747 | WP_000205750.1 | conjugal transfer pilus acetylase TraX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | estIa / paa / hlyD / hlyB / hlyA / hlyC | 1..137079 | 137079 | |
| - | flank | IS/Tn | - | - | 35904..36407 | 503 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5528.64 Da Isoelectric Point: 8.7678
>T167518 WP_001367749.1 NZ_CP058791:c35025-34876 [Shigella flexneri]
MTKYALIGVLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGVLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T167518 NZ_CP075140:471493-471768 [Salmonella enterica]
ATGAAACAGGTATTAAAAGATTTTGACGTCGCAGACTATTTAGAGGACGAGGATGATGTTATCGCTTATCTAAATGCCGT
TATTGCCGAGGGTGACAATAAACAACTTTTCATTGCGCTGGGCAACATTGCAAGAGCAAGAAATATAAGCCGTATTTCAA
AAGAAACCGGAATCAGCAGGGAGGGAATTTATAAAGCACTTTCAGGCGATGGAAATCCATCATTTAACACCCTTTCTAAA
ATAACTAAAGCGATGGGGTTAGATCTTCACTTTTAA
ATGAAACAGGTATTAAAAGATTTTGACGTCGCAGACTATTTAGAGGACGAGGATGATGTTATCGCTTATCTAAATGCCGT
TATTGCCGAGGGTGACAATAAACAACTTTTCATTGCGCTGGGCAACATTGCAAGAGCAAGAAATATAAGCCGTATTTCAA
AAGAAACCGGAATCAGCAGGGAGGGAATTTATAAAGCACTTTCAGGCGATGGAAATCCATCATTTAACACCCTTTCTAAA
ATAACTAAAGCGATGGGGTTAGATCTTCACTTTTAA
Antitoxin
Download Length: 62 bp
>AT167518 NZ_CP058791:35069-35130 [Shigella flexneri]
TTAAGGTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
