Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1828657..1829159 Replicon chromosome
Accession NZ_CP058790
Organism Shigella flexneri strain STLIN_6

Toxin (Protein)


Gene name yoeB Uniprot ID D8A584
Locus tag HZT08_RS08770 Protein ID WP_000767828.1
Coordinates 1828905..1829159 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HZT08_RS08765 Protein ID WP_001259255.1
Coordinates 1828657..1828908 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT08_RS08740 (1823835) 1823835..1824902 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
HZT08_RS08745 (1824902) 1824902..1825972 - 1071 WP_001564244.1 histidinol-phosphate transaminase -
HZT08_RS08750 (1825969) 1825969..1827273 - 1305 WP_001493159.1 histidinol dehydrogenase -
HZT08_RS08755 (1827279) 1827279..1828178 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
HZT08_RS08760 (1828324) 1828324..1828374 - 51 WP_001364200.1 his operon leader peptide -
HZT08_RS08765 (1828657) 1828657..1828908 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HZT08_RS08770 (1828905) 1828905..1829159 + 255 WP_000767828.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HZT08_RS08775 (1829242) 1829242..1830066 + 825 WP_000754758.1 SDR family oxidoreductase -
HZT08_RS08780 (1830112) 1830112..1831041 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
HZT08_RS08785 (1831256) 1831256..1831318 + 63 WP_010723108.1 membrane protein YoeI -
HZT08_RS08790 (1831308) 1831308..1832666 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
HZT08_RS08795 (1832845) 1832845..1833903 + 1059 WP_000492340.1 thiosulfate utilization transporter TsuA/YeeE -
HZT08_RS08800 (1833917) 1833917..1834144 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10169.56 Da        Isoelectric Point: 8.0353

>T167499 WP_000767828.1 NZ_CP058790:1828905-1829159 [Shigella flexneri]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEDHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T167499 NZ_CP075137:3720143-3720388 [Salmonella enterica]
ATGAATGCCTCCGGCGCCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCACCTGTTACTCACAAATCCCCAGCGG
CGACTGCCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACGGTGAAGATTTCGGACGGGTGTATTGTGCTAATGG
CGGACGGTAACGAGGTGCAGAAGCTGTGCGAACAGCTTTATCAGGCTGAACAGGTAGTTAAGGGGATGTGGGACGTGATT
GTTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT167499 WP_001259255.1 NZ_CP058790:1828657-1828908 [Shigella flexneri]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT167499 NZ_CP075137:c3720352-3719986 [Salmonella enterica]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGTGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCG
GCCAGTACCGGGCGGTGATGAGCAACCGGCTACCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G465

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References