Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 601471..602270 Replicon chromosome
Accession NZ_CP058790
Organism Shigella flexneri strain STLIN_6

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag HZT08_RS02960 Protein ID WP_000347273.1
Coordinates 601471..601935 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag HZT08_RS02965 Protein ID WP_001307405.1
Coordinates 601935..602270 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT08_RS02930 (596472) 596472..596906 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
HZT08_RS02935 (596924) 596924..597802 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
HZT08_RS02940 (597792) 597792..598571 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
HZT08_RS02945 (598582) 598582..599055 - 474 WP_106489547.1 PTS N-acetylgalactosamine transporter subunit IIB -
HZT08_RS02950 (599078) 599078..600358 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
HZT08_RS02955 (600607) 600607..601416 + 810 WP_000072180.1 aga operon transcriptional regulator AgaR -
HZT08_RS02960 (601471) 601471..601935 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
HZT08_RS02965 (601935) 601935..602270 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
HZT08_RS02970 (602419) 602419..603990 - 1572 WP_001273741.1 galactarate dehydratase -
HZT08_RS02975 (604365) 604365..605699 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
HZT08_RS02980 (605715) 605715..606485 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T167495 WP_000347273.1 NZ_CP058790:c601935-601471 [Shigella flexneri]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T167495 NZ_CP075137:1926148-1926480 [Salmonella enterica]
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCGATTGCCGGCCATGAGCAAAGTGGAAAACGTCCGGTACTCAT
CGTATCGCAAGCATCGTTTAACAAGCTGACCCGACTACCCGTTATTGTTCCCGTCACCAGCGGCGGAAACTTTGCCCGCG
CAGCCGGTTTTACCGTCTCCCTGGACGGCGCGGGAACAAAAACAACGGGCGTTATTCGCTGCGACCAGCCCAGAACTATT
GATATGGGCGCCCGGAACGGTAAGCGGCTGGAACGTATACCCGACGCTGTTGTGAATGAAGTGCTGGCCCGACTGGAGGC
CATTTTGAGCTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT167495 WP_001307405.1 NZ_CP058790:c602270-601935 [Shigella flexneri]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT167495 NZ_CP075137:1925890-1926147 [Salmonella enterica]
ATGTATACCACTCGTCTGAAAAAGGTTGGCGGATCCGTCATGCTGGCTGTTCCTCCCGCCGTGCTGAAAACGCTGGGGCT
GTCGACGGACAGCGAAGTGGGCATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCACGTTATTCGC
TTGAGGAACTGCTGGCGCAGTGCGATCCGCACGCTGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References