Detailed information of TA system TA167492

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 48206..48475
• Replicon: plasmid unnamed2
• Accession: NZ_CP058788
• Organism: Shigella flexneri strain STLIN_4

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: HZT07_RS23840
• Protein ID: WP_001372321.1
• Coordinates: 48350..48475 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	48206..48271 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT07_RS23790	43207..43419	+	213	WP_074154109.1	hypothetical protein	-
HZT07_RS23795	43359..43589	+	231	WP_001380705.1	hypothetical protein	-
HZT07_RS23800	43830..44036	+	207	WP_000547968.1	hypothetical protein	-
HZT07_RS23805	44062..44514	+	453	WP_000290842.1	single-stranded DNA-binding protein	-
HZT07_RS23810	44576..44809	+	234	WP_063085740.1	DUF905 family protein	-
HZT07_RS23815	44874..46832	+	1959	WP_063072993.1	ParB/RepB/Spo0J family partition protein	-
HZT07_RS23820	46887..47321	+	435	WP_000845907.1	conjugation system SOS inhibitor PsiB	-
HZT07_RS23825	47318..48037	+	720	WP_001276240.1	plasmid SOS inhibition protein A	-
HZT07_RS23830	48049..48237	-	189	WP_001299721.1	hypothetical protein	-
-	48049..48273	+	225	NuclAT_0	-	-
-	48049..48273	+	225	NuclAT_0	-	-
-	48049..48273	+	225	NuclAT_0	-	-
-	48049..48273	+	225	NuclAT_0	-	-
-	48206..48271	-	66	-	-	Antitoxin
HZT07_RS23835	48259..48408	+	150	Protein_55	plasmid maintenance protein Mok	-
HZT07_RS23840	48350..48475	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
HZT07_RS23845	48695..48925	+	231	WP_001426396.1	hypothetical protein	-
HZT07_RS23850	48923..49096	-	174	Protein_58	hypothetical protein	-
HZT07_RS23855	49166..49372	+	207	WP_000547968.1	hypothetical protein	-
HZT07_RS23860	49397..49684	+	288	WP_000107535.1	hypothetical protein	-
HZT07_RS23865	49803..50624	+	822	WP_001234469.1	DUF932 domain-containing protein	-
HZT07_RS23870	50921..51523	-	603	WP_000243712.1	transglycosylase SLT domain-containing protein	-
HZT07_RS23875	51844..52227	+	384	WP_001151524.1	conjugal transfer relaxosome DNA-binding protein TraM	-
HZT07_RS23880	52414..53103	+	690	WP_047402313.1	conjugal transfer transcriptional regulator TraJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	vat	1..85618	85618

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T167492 WP_001372321.1 NZ_CP058788:48350-48475 [Shigella flexneri]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T167492 NZ_CP075137:335746-336114 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCAGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGCGCCTGA

Antitoxin

Nucleotide

• Length: 66 bp

>AT167492 NZ_CP058788:c48271-48206 [Shigella flexneri]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Antitoxin