Detailed information of TA system TA167467

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 712825..713518
• Replicon: chromosome
• Accession: NZ_CP058786
• Organism: Shigella flexneri strain STLIN_4

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: S1EZG2
• Locus tag: HZT07_RS03475
• Protein ID: WP_000415584.1
• Coordinates: 712825..713121 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: S1EBV2
• Locus tag: HZT07_RS03480
• Protein ID: WP_000650107.1
• Coordinates: 713123..713518 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT07_RS03440 (707913)	707913..708227	-	315	WP_000958598.1	putative quinol monooxygenase	-
HZT07_RS03445 (708258)	708258..708839	-	582	WP_000065430.1	NADPH:quinone oxidoreductase MdaB	-
HZT07_RS03450 (709158)	709158..709490	+	333	WP_000917684.1	DUF2645 family protein	-
HZT07_RS03455 (709536)	709536..710885	-	1350	WP_001618857.1	quorum sensing histidine kinase QseC	-
HZT07_RS03460 (710882)	710882..711541	-	660	WP_001221493.1	quorum sensing response regulator transcription factor QseB	-
HZT07_RS03465 (711693)	711693..712085	+	393	WP_000712658.1	OB fold stress tolerance protein YgiW	-
HZT07_RS03470 (712138)	712138..712620	+	483	WP_000183505.1	GyrI-like domain-containing protein	-
HZT07_RS03475 (712825)	712825..713121	+	297	WP_000415584.1	type II toxin-antitoxin system toxin MqsR	Toxin
HZT07_RS03480 (713123)	713123..713518	+	396	WP_000650107.1	type II toxin-antitoxin system antitoxin MqsA	Antitoxin
HZT07_RS03485 (713651)	713651..715258	+	1608	WP_001295629.1	ABC transporter substrate-binding protein	-
HZT07_RS03490 (715396)	715396..717654	+	2259	WP_240763441.1	DNA topoisomerase IV subunit A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Zinc finger, MqsA-type (3-47)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11231.96 Da
• Isoelectric Point: 8.9070

>T167467 WP_000415584.1 NZ_CP058786:712825-713121 [Shigella flexneri]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Nucleotide

• Length: 297 bp

>T167467 NZ_CP075134:211320-211805 [Salmonella enterica subsp. enterica serovar Saintpaul]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14703.10 Da
• Isoelectric Point: 9.2136

>AT167467 WP_000650107.1 NZ_CP058786:713123-713518 [Shigella flexneri]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Nucleotide

• Length: 396 bp

>AT167467 NZ_CP075134:211045-211332 [Salmonella enterica subsp. enterica serovar Saintpaul]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Toxin

• PDB: 3HI2

Antitoxin

• PDB: 3HI2
• PDB: 3GA8
• PDB: 3O9X
• PDB: 2KZ8
• PDB: 3FMY
• PDB: 3GN5
• AlphaFold DB: A0A7U9LU65