Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 604927..605726 Replicon chromosome
Accession NZ_CP058786
Organism Shigella flexneri strain STLIN_4

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag HZT07_RS02945 Protein ID WP_000347273.1
Coordinates 604927..605391 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag HZT07_RS02950 Protein ID WP_001307405.1
Coordinates 605391..605726 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT07_RS02915 (599928) 599928..600362 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
HZT07_RS02920 (600380) 600380..601258 - 879 WP_001300474.1 PTS N-acetylgalactosamine transporter subunit IID -
HZT07_RS02925 (601248) 601248..602027 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
HZT07_RS02930 (602038) 602038..602511 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
HZT07_RS02935 (602534) 602534..603814 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
HZT07_RS02940 (604063) 604063..604872 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
HZT07_RS02945 (604927) 604927..605391 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
HZT07_RS02950 (605391) 605391..605726 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
HZT07_RS02955 (605875) 605875..607446 - 1572 WP_001723936.1 galactarate dehydratase -
HZT07_RS02960 (607821) 607821..609155 + 1335 WP_001723935.1 galactarate/glucarate/glycerate transporter GarP -
HZT07_RS02965 (609171) 609171..609941 + 771 WP_001723934.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T167465 WP_000347273.1 NZ_CP058786:c605391-604927 [Shigella flexneri]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T167465 NZ_CP075132:c4778226-4777915 [Salmonella enterica subsp. enterica serovar Inverness]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT167465 WP_001307405.1 NZ_CP058786:c605726-605391 [Shigella flexneri]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT167465 NZ_CP075132:c4777914-4777624 [Salmonella enterica subsp. enterica serovar Inverness]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References