Detailed information of TA system TA167461

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 3640230..3640771
• Replicon: chromosome
• Accession: NZ_CP058780
• Organism: Shigella flexneri strain STLIN_17

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: S1FHQ9
• Locus tag: HZT03_RS17735
• Protein ID: WP_000615979.1
• Coordinates: 3640493..3640771 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: -
• Locus tag: HZT03_RS17730
• Protein ID: WP_094337016.1
• Coordinates: 3640230..3640490 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT03_RS17710 (3635913)	3635913..3636698	-	786	WP_072132640.1	putative lateral flagellar export/assembly protein LafU	-
HZT03_RS17715 (3636670)	3636670..3638382	+	1713	Protein_3481	flagellar biosynthesis protein FlhA	-
HZT03_RS17720 (3638598)	3638598..3639095	-	498	WP_000006261.1	REP-associated tyrosine transposase RayT	-
HZT03_RS17725 (3639271)	3639271..3640044	-	774	WP_001353765.1	C40 family peptidase	-
HZT03_RS17730 (3640230)	3640230..3640490	+	261	WP_094337016.1	type II toxin-antitoxin system antitoxin DinJ	Antitoxin
HZT03_RS17735 (3640493)	3640493..3640771	+	279	WP_000615979.1	type II toxin-antitoxin system mRNA interferase toxin YafQ	Toxin
HZT03_RS17740 (3640927)	3640927..3641667	+	741	WP_001225679.1	peptidoglycan meso-diaminopimelic acid protein amidase	-
HZT03_RS17745 (3641638)	3641638..3642405	-	768	WP_000333379.1	class II glutamine amidotransferase	-
HZT03_RS17750 (3642611)	3642611..3643189	-	579	WP_000284050.1	D-sedoheptulose 7-phosphate isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-84)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10830.62 Da
• Isoelectric Point: 10.0702

>T167461 WP_000615979.1 NZ_CP058780:3640493-3640771 [Shigella flexneri]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Nucleotide

• Length: 279 bp

>T167461 NZ_CP075132:c2778815-2778402 [Salmonella enterica subsp. enterica serovar Inverness]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9407.77 Da
• Isoelectric Point: 5.0758

>AT167461 WP_094337016.1 NZ_CP058780:3640230-3640490 [Shigella flexneri]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSESGVDVHKAKDADDL
FDKLGI

Nucleotide

• Length: 261 bp

>AT167461 NZ_CP075132:c2779062-2778796 [Salmonella enterica subsp. enterica serovar Inverness]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: S1FHQ9