Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 788942..789635 Replicon chromosome
Accession NZ_CP058771
Organism Shigella flexneri strain STLIN_11

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HZS97_RS03860 Protein ID WP_000415584.1
Coordinates 788942..789238 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HZS97_RS03865 Protein ID WP_000650107.1
Coordinates 789240..789635 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS97_RS03825 (784030) 784030..784344 - 315 WP_000958598.1 putative quinol monooxygenase -
HZS97_RS03830 (784375) 784375..784956 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HZS97_RS03835 (785275) 785275..785607 + 333 WP_000917684.1 DUF2645 family protein -
HZS97_RS03840 (785653) 785653..787002 - 1350 WP_001618857.1 quorum sensing histidine kinase QseC -
HZS97_RS03845 (786999) 786999..787658 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
HZS97_RS03850 (787810) 787810..788202 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HZS97_RS03855 (788255) 788255..788737 + 483 WP_000183505.1 GyrI-like domain-containing protein -
HZS97_RS03860 (788942) 788942..789238 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HZS97_RS03865 (789240) 789240..789635 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HZS97_RS03870 (789768) 789768..791375 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HZS97_RS03875 (791513) 791513..793771 + 2259 WP_240763441.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T167413 WP_000415584.1 NZ_CP058771:788942-789238 [Shigella flexneri]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T167413 NZ_CP075125:3561397-3561615 [Salmonella enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT167413 WP_000650107.1 NZ_CP058771:789240-789635 [Shigella flexneri]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT167413 NZ_CP075125:3560995-3561369 [Salmonella enterica]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCTCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References