Detailed information of TA system TA167413

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 788942..789635
• Replicon: chromosome
• Accession: NZ_CP058771
• Organism: Shigella flexneri strain STLIN_11

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: S1EZG2
• Locus tag: HZS97_RS03860
• Protein ID: WP_000415584.1
• Coordinates: 788942..789238 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: S1EBV2
• Locus tag: HZS97_RS03865
• Protein ID: WP_000650107.1
• Coordinates: 789240..789635 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZS97_RS03825 (784030)	784030..784344	-	315	WP_000958598.1	putative quinol monooxygenase	-
HZS97_RS03830 (784375)	784375..784956	-	582	WP_000065430.1	NADPH:quinone oxidoreductase MdaB	-
HZS97_RS03835 (785275)	785275..785607	+	333	WP_000917684.1	DUF2645 family protein	-
HZS97_RS03840 (785653)	785653..787002	-	1350	WP_001618857.1	quorum sensing histidine kinase QseC	-
HZS97_RS03845 (786999)	786999..787658	-	660	WP_001221493.1	quorum sensing response regulator transcription factor QseB	-
HZS97_RS03850 (787810)	787810..788202	+	393	WP_000712658.1	OB fold stress tolerance protein YgiW	-
HZS97_RS03855 (788255)	788255..788737	+	483	WP_000183505.1	GyrI-like domain-containing protein	-
HZS97_RS03860 (788942)	788942..789238	+	297	WP_000415584.1	type II toxin-antitoxin system toxin MqsR	Toxin
HZS97_RS03865 (789240)	789240..789635	+	396	WP_000650107.1	type II toxin-antitoxin system antitoxin MqsA	Antitoxin
HZS97_RS03870 (789768)	789768..791375	+	1608	WP_001295629.1	ABC transporter substrate-binding protein	-
HZS97_RS03875 (791513)	791513..793771	+	2259	WP_240763441.1	DNA topoisomerase IV subunit A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Zinc finger, MqsA-type (3-47)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11231.96 Da
• Isoelectric Point: 8.9070

>T167413 WP_000415584.1 NZ_CP058771:788942-789238 [Shigella flexneri]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Nucleotide

• Length: 297 bp

>T167413 NZ_CP075125:3561397-3561615 [Salmonella enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14703.10 Da
• Isoelectric Point: 9.2136

>AT167413 WP_000650107.1 NZ_CP058771:789240-789635 [Shigella flexneri]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Nucleotide

• Length: 396 bp

>AT167413 NZ_CP075125:3560995-3561369 [Salmonella enterica]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCTCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Structures

Toxin

• PDB: 3HI2

Antitoxin

• AlphaFold DB: A0A7U9LU65