Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 333174..333820 Replicon chromosome
Accession NZ_CP058758
Organism Klebsiella pneumoniae strain STLIN_3

Toxin (Protein)


Gene name higB Uniprot ID A0A231WWF9
Locus tag HZT06_RS01585 Protein ID WP_004174016.1
Coordinates 333174..333521 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A231WWU8
Locus tag HZT06_RS01590 Protein ID WP_004174017.1
Coordinates 333521..333820 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT06_RS01575 (HZT06_01575) 329110..330543 + 1434 WP_002920564.1 glycogen synthase GlgA -
HZT06_RS01580 (HZT06_01580) 330561..333008 + 2448 WP_002920561.1 glycogen phosphorylase -
HZT06_RS01585 (HZT06_01585) 333174..333521 + 348 WP_004174016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZT06_RS01590 (HZT06_01590) 333521..333820 + 300 WP_004174017.1 XRE family transcriptional regulator Antitoxin
HZT06_RS01595 (HZT06_01595) 333883..335391 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
HZT06_RS01600 (HZT06_01600) 335596..335925 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
HZT06_RS01605 (HZT06_01605) 335976..336806 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
HZT06_RS01610 (HZT06_01610) 336856..337614 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13518.55 Da        Isoelectric Point: 6.2327

>T167389 WP_004174016.1 NZ_CP058758:333174-333521 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T167389 NZ_CP075121:c14802-14497 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10844.64 Da        Isoelectric Point: 10.1464

>AT167389 WP_004174017.1 NZ_CP058758:333521-333820 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT167389 NZ_CP075121:c15022-14804 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGACAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A231WWF9

Antitoxin

Source ID Structure
AlphaFold DB A0A231WWU8

References