Detailed information of TA system TA167381

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 4283338..4283984
• Replicon: chromosome
• Accession: NZ_CP058752
• Organism: Klebsiella pneumoniae strain STLIN_19

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A231WWF9
• Locus tag: HZT05_RS20905
• Protein ID: WP_004174016.1
• Coordinates: 4283338..4283685 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HZT05_RS20910
• Protein ID: WP_240726168.1
• Coordinates: 4283685..4283984 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT05_RS20895 (4279274)	4279274..4280707	+	1434	WP_002920564.1	glycogen synthase GlgA	-
HZT05_RS20900 (4280725)	4280725..4283172	+	2448	WP_002920561.1	glycogen phosphorylase	-
HZT05_RS20905 (4283338)	4283338..4283685	+	348	WP_004174016.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HZT05_RS20910 (4283685)	4283685..4283984	+	300	WP_240726168.1	XRE family transcriptional regulator	Antitoxin
HZT05_RS20915 (4284047)	4284047..4285555	-	1509	WP_002920554.1	glycerol-3-phosphate dehydrogenase	-
HZT05_RS20920 (4285760)	4285760..4286089	+	330	WP_002920552.1	thiosulfate sulfurtransferase GlpE	-
HZT05_RS20925 (4286140)	4286140..4286970	+	831	WP_004188317.1	rhomboid family intramembrane serine protease GlpG	-
HZT05_RS20930 (4287020)	4287020..4287778	+	759	WP_002920548.1	DeoR/GlpR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-107)

Antitoxin

• HigA2-like, helix-turn-helix domain (9-87)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13518.55 Da
• Isoelectric Point: 6.2327

>T167381 WP_004174016.1 NZ_CP058752:4283338-4283685 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Nucleotide

• Length: 348 bp

>T167381 NZ_CP075120:3405638-3405856 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10903.66 Da
• Isoelectric Point: 10.1464

>AT167381 WP_240726168.1 NZ_CP058752:4283685-4283984 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAAWG
GELSINVTLPTGKKVSFNL

Nucleotide

• Length: 300 bp

>AT167381 NZ_CP075120:3405236-3405610 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Structures

Toxin

• AlphaFold DB: A0A231WWF9