Detailed information of TA system TA167373

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 2492007..2492604
• Replicon: chromosome
• Accession: NZ_CP058752
• Organism: Klebsiella pneumoniae strain STLIN_19

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A9J6S5A1
• Locus tag: HZT05_RS12465
• Protein ID: WP_004893639.1
• Coordinates: 2492287..2492604 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: R4YH91
• Locus tag: HZT05_RS12460
• Protein ID: WP_004142561.1
• Coordinates: 2492007..2492294 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT05_RS12430 (2488214)	2488214..2488462	+	249	WP_002893037.1	DUF1158 domain-containing protein	-
HZT05_RS12435 (2488480)	2488480..2488821	-	342	WP_002893035.1	RamA family antibiotic efflux transcriptional regulator	-
HZT05_RS12440 (2488852)	2488852..2489967	-	1116	WP_012737592.1	MBL fold metallo-hydrolase	-
HZT05_RS12445 (2490147)	2490147..2490728	+	582	WP_004176968.1	TetR/AcrR family transcriptional regulator	-
HZT05_RS12450 (2490728)	2490728..2491096	+	369	WP_004142557.1	MmcQ/YjbR family DNA-binding protein	-
HZT05_RS12455 (2491216)	2491216..2491869	+	654	WP_004178896.1	oxygen-insensitive NAD(P)H nitroreductase	-
HZT05_RS12460 (2492007)	2492007..2492294	-	288	WP_004142561.1	helix-turn-helix transcriptional regulator	Antitoxin
HZT05_RS12465 (2492287)	2492287..2492604	-	318	WP_004893639.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HZT05_RS12470 (2492789)	2492789..2493832	-	1044	WP_240726521.1	DUF2157 domain-containing protein	-
HZT05_RS12475 (2494502)	2494502..2495368	-	867	WP_004151823.1	helix-turn-helix transcriptional regulator	-
HZT05_RS12480 (2495477)	2495477..2496904	+	1428	WP_101998785.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-100)

Antitoxin

• Cro/C1-type helix-turn-helix domain (38-88)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12100.35 Da
• Isoelectric Point: 11.2767

>T167373 WP_004893639.1 NZ_CP058752:c2492604-2492287 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPSIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Nucleotide

• Length: 318 bp

>T167373 NZ_CP075120:200452-200937 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGTGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10771.46 Da
• Isoelectric Point: 10.2212

>AT167373 WP_004142561.1 NZ_CP058752:c2492294-2492007 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Nucleotide

• Length: 288 bp

>AT167373 NZ_CP075120:200177-200464 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0S3DIQ1