Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 3569662..3570341 Replicon chromosome
Accession NZ_CP058748
Organism Escherichia coli strain STLIN_13

Toxin (Protein)


Gene name higB Uniprot ID A0A0A1A1R1
Locus tag HZS99_RS17230 Protein ID WP_000057541.1
Coordinates 3570039..3570341 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1QAY3
Locus tag HZS99_RS17225 Protein ID WP_000806442.1
Coordinates 3569662..3570003 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS99_RS17215 (3565905) 3565905..3566837 - 933 WP_000883039.1 glutaminase A -
HZS99_RS17220 (3567100) 3567100..3569604 + 2505 WP_061092784.1 copper-exporting P-type ATPase CopA -
HZS99_RS17225 (3569662) 3569662..3570003 - 342 WP_000806442.1 HigA family addiction module antitoxin Antitoxin
HZS99_RS17230 (3570039) 3570039..3570341 - 303 WP_000057541.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZS99_RS17235 (3570474) 3570474..3571268 + 795 WP_000365157.1 TraB/GumN family protein -
HZS99_RS17240 (3571472) 3571472..3571951 + 480 WP_000186626.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
HZS99_RS17245 (3571988) 3571988..3573640 - 1653 WP_000771723.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
HZS99_RS17250 (3573858) 3573858..3575078 + 1221 WP_001251634.1 fosmidomycin MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11795.37 Da        Isoelectric Point: 10.2638

>T167351 WP_000057541.1 NZ_CP058748:c3570341-3570039 [Escherichia coli]
MAQKNNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELFLDPHNY

Download         Length: 303 bp

>T167351 NZ_CP075116:3548854-3549156 [Salmonella enterica subsp. enterica serovar Stanleyville]
GTGTCCATTTCCAAAACCCAGCGCCGTTATCAGGTGGGCTACATCAGCGTCCGCCACGAGAACAGCAAAACCCACATGAC
CACCTATTACTCGCGCATCCCCAGCCTGCACCTTAAGGGCGACTGGCTGGCAGAAGCGGGATTTGATACCGGGGCGAGCG
TGACCGTGAAGATCTCCGAGGGGTGTTTGACTCTGATTGCGGAGCGCGACGAGGTGCAGGAGCTGCGGGAGGAACTTTAT
CAGGTTAAACAGGTGGTTAAAGGAATGAAGGTCGGGATATCCGGCGTATTACGCGAGGTATAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13171.10 Da        Isoelectric Point: 5.7790

>AT167351 WP_000806442.1 NZ_CP058748:c3570003-3569662 [Escherichia coli]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVAEYLARREERAKKVA

Download         Length: 342 bp

>AT167351 NZ_CP075116:c3549105-3548897 [Salmonella enterica subsp. enterica serovar Stanleyville]
CTGTTTAACCTGATAAAGTTCCTCCCGCAGCTCCTGCACCTCGTCGCGCTCCGCAATCAGAGTCAAACACCCCTCGGAGA
TCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTTCTGCCAGCCAGTCGCCCTTAAGGTGCAGGCTGGGGATGCGC
GAGTAATAGGTGGTCATGTGGGTTTTGCTGTTCTCGTGGCGGACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A1A1R1

Antitoxin

Source ID Structure
PDB 2EBY
AlphaFold DB S1QAY3

References